Vitamin-targeted imaging agents
AssigneeEndocyte, Inc.
InventorsChristopher P. Leamon, Matthew A. Parker
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds and methods for targeting radionuclide-based imaging agents to cells having receptors for a vitamin, or vitamin receptor binding derivative or analog thereof, by using such a vitamin as the targeting ligand for the imaging agent. The vitamin-based compounds can be used to target radionuclides to cells, such as a variety of tumor cell types, for use in diagnostic imaging of the targeted cells.
Claims69
A method of imaging a tumor in a patient, the method comprising the step of
- administering to the patient a composition comprising an effective amount of a compound and a pharmaceutically acceptable carrier, wherein the compound has the formula
- and wherein M is a radionuclide.
A method of visualizing a tumor in a patient by imaging the tumor, the method comprising the steps of
- administering to the patient a composition comprising an effective amount of a compound and a pharmaceutically acceptable carrier, wherein the compound has the formula
- and wherein M is a radionuclide;
- and visualizing the tumor by imaging.
A composition comprising a compound of the formula
- and one or more pharmaceutically acceptable carriers.
A composition comprising a compound of the formula
- and one or more pharmaceutically acceptable carriers, wherein M is a radionuclide.
A composition comprising a compound of the formula
- and one or more pharmaceutically acceptable carriers, wherein M is a radionuclide.
A kit comprising a compound of the formula
- sodium α-D-glucoheptonate, tin (II) chloride, and one or more pharmaceutically acceptable carriers.
Dependencies are inferred from the claim text.