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US 8,834,423 B2Granted
Dissolvable microneedle arrays for transdermal delivery to human skin
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsLouis D. Falo, Jr., Geza Erdos, O. Burak Ozdoganlar
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Abstract
A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion.
Claims9
A dissolvable microneedle array comprising:
- a base portion;
- and
- a plurality of microneedles, the microneedles extending from a surface of the base portion and being pre-formed to have a shape that comprises a first cross-sectional dimension at a top portion, a second cross-sectional dimension at a bottom portion, and a third cross-sectional dimension at an intermediate portion, wherein the intermediate portion is located between the top portion and the bottom portion, and the third cross-sectional dimension is greater than the first and second cross-sectional dimensions, such that the bottom portion tapers inward on all sides to the second cross-sectional dimension,
- wherein the respective microneedles of the plurality of microneedles extend from a base surface that surrounds the respective microneedles, and
- wherein at least the top portion comprises a bioactive component,
- wherein respective microneedles generally taper from the intermediate portion to a point above the intermediate portion and generally taper from the intermediate portion to a smaller cross-sectional dimension adjacent an area where the microneedle contacts the base portion,
- wherein each microneedle defines a vertically-layered, laminated structure with the portion of the microneedle comprising the bioactive component forming a bioactive layer that is parallel to the base portion.
4 more elements
Dependencies are inferred from the claim text.