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US 8,829,241 B2Granted
Continuous crystallisation process of iodinated phenyl derivatives
AssigneeGe Healthcare Limited
InventorsJan Cervenka, Khalid Hussain, Arne W. Aabye
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Abstract
The invention describes a process for the purification of iodinated aryl compounds where the purification is performed by continuous crystallization of a crude product in a solvent with addition of anti-solvent. The continuous crystallization process is performed in one or more crystallizers at a temperature up to the boiling point of the content of the crystallizer.
Claims25
A continuous crystallization process for the purification of a crude product comprising iodinated phenyl compounds comprising the following steps:
- i) feeding a solution comprising said crude product in a solvent into a crystallizer;
- ii) feeding an anti-solvent into said crystallizer;
- iii) achieving optimum supersaturation by either balancing the amount of said anti-solvent fed to the crystallizer or adjusting the temperature of the crystallization process;
- iv) withdrawing crystallized iodinated phenyl compound as a suspension;
- and
- v) establishing steady state conditions wherein:
- said solution comprising said crude product and said anti-solvent are fed into the crystallizer at constant rates;
- said crystallized iodinated phenyl compound is withdrawn as a suspension at constant rate;
- and
- the volume load of said crystallizer is kept constant.
7 more elements
Dependencies are inferred from the claim text.