US 8,828,686 B2 · Polynucleotides encoding therapeutic inhibitors of PAI-1

Abstract

The invention relates to mammalian PAI-I ligands and modulators. In particular, the invention relates to polypeptides, polypeptide compositions and polynucleotides that encode polypeptides that are ligands and/or modulators of PAI-I. The invention also relates to polyligands that are homopolyligands or heteropolyligands that modulate PAI-I activity. The invention also relates to ligands and polyligands localized to a region of a cell. The invention also relates to localization tethers and promoter sequences that can be used to provide spatial control of the PAI-I ligands and polyligands. The invention also relates to inducible gene switches that can be used to provide temporal control of the PAI-I ligands and polyligands. The invention also relates to methods of treating or preventing atherosclerosis. The invention also relates to methods of treating or preventing fibrosis.

Claims13

Dependent claims

An isolated polynucleotide encoding a polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO:

25, wherein said amino acid sequence, that is at least 95% identical to SEQ ID NO:
25 binds to plasminogen activator inhibitor 1 (PAI-1) thereby inhibiting the activity of PAI-1 to inhibit plasminogen activator.

Dependencies are inferred from the claim text.

Facts

Application

13/769,144Filed 15 Feb 2013 · division

Priority

9 Jan 2008

Published

US 2013/0267022 A110 Oct 2013

Granted

9 Sep 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification17 codes

C07K 14/001
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: by chemical synthesis
A61P 7/02
Drugs for disorders of the blood or the extracellular fluid: antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A61P 9/00
Drugs for disorders of the cardiovascular system
A61P 9/10
Drugs for disorders of the cardiovascular system: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary…

Family

Application61/020,137Us provisional application · filed 9 Jan 2008

Application61/080,640Us provisional application · filed 14 Jul 2008

PCT/US2009/000155Parent of this division · filed 9 Jan 2009

US 2013/0267022 A1Pre-grant publication · published 10 Oct 2013

Application12/812,127Parent of this division

US 8,431,363 B2Parent of this division

US 2011/0055940 A1Published application

US 8,828,686 B2This patent

From the US filing history. Foreign family members aren’t listed.

Polynucleotides encoding therapeutic inhibitors of PAI-1

Life of this patent

Polynucleotides encoding therapeutic inhibitors of PAI-1

Life of this patent

Abstract

Claims13