Monomeric forms of human aminoacyl-t-RNA synthetases having non-canonical biological activities
AssigneeThe Scripps Research Institute
InventorsPaul Schimmel, Xiang-Lei Yang, Bonnie Slike
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Abstract
Isolated monomelic aminoacyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
Claims5
A method of increasing an inflammatory response in a subject, comprising administering to the subject the modified tyrosyl-tRNA (TyrRS) synthetase polypeptide having a non-canonical biological activity, wherein the polypeptide is substantially in a monomeric form under physiological conditions or in solution, and comprises one or more stabilizing modifications relative to a wild-type TyrRS sequence that reduce its ability to dimerize with itself or with another TyrRS polypeptide wherein said TyrRS polypeptide comprises a deletion of amino acid Pro 159, Leu160 and Leu161 (Δ159-161) relative to SEQ ID NO:
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Dependencies are inferred from the claim text.