Diagnostic methods and systems based on urine analysis

A diagnostic method for detecting at least one change in a urinary parameter indicative of a body malfunction, the method comprising at least semi-continuously monitoring in real time at least one of a sodium level, an oxygen level, a potassium level, and combinations thereof in the urine of a catheterized patient;

• whereby at least one parameter is monitored so as to detect one or more changes in the at least one parameter to reflect at least one of a fluid state, an electrolyte balance, a kidney state, a kidney perfusion and an organ perfusion in the patient, indicative of the body malfunction in the patient, wherein the monitoring comprises arranging electrodes perpendicularly to and in the flow of urine through a patient's catheter system, in line to said system, wherein said electrodes comprise a glass electrode;
• receiving urine from the patient to said electrodes;
• and analyzing said one or more levels in real time by said electrodes at least once every five minutes without interruption to the flow of urine.

A monitoring apparatus for in-line monitoring of urine from a patient, the patient having a catheter inserted therein, the catheter having a distal portion extending outside of the patient, the apparatus comprising:

• a catheter tube fluidly connected to said distal portion;
• an electrode system fluidly connected to said catheter tube, said electrode system comprising a receiving connector for fluidly connecting to said catheter tube, and a chamber fluidly connected to said receiving connector, said chamber comprising at least one electrode arranged perpendicularly to a flow of urine through said chamber, wherein the tip of said electrode is immersed in said flow of urine, wherein said flow of urine flows directly from the patient through the catheter, through said catheter tube, into said receiving connector and into said chamber for in-line analysis without interruption, wherein said chamber further comprises a negative pressure flow tube to provide flow compensation.