Neural modulation devices and methods

A method of treating a gastrointestinal disorder or a condition associated with excess weight in a subject in need thereof comprising:

• programming an implantable neuroregulator to apply a therapy cycle to an electrode placed at a vagus nerve, wherein each therapy cycle comprises a) a high frequency burst of electrical signal having a first selected frequency of at least 1000 Hz, wherein the high frequency burst of electrical signals comprises one or more pulses that have a pulse width of about 0.01 milliseconds to about 0.09 milliseconds, and a current of about 0.1 to 20 mAmps;
• b) more than one burst of a second low frequency electrical signal, each burst having a second selected frequency of at least 40 Hz and less than 150 Hz, wherein each of the bursts of low frequency electrical signals comprises one or more pulses that have a pulse width of about 0.05 microseconds to about 0.5 microseconds, a current of about 0.1 to 20 mAmps and a delay period between each burst;
• wherein the high frequency burst and low frequency burst are delivered during the same therapy cycle and at least partially downregulate activity on the nerve;
• c) an on period of at least 2 minutes d) an off period, wherein the off period is selected to allow at least partial recovery of nerve activity;
• and e) a total charge of about 5 to 1000 microcoulombs or less per therapy cycle.