Method and compositions using a chimeric antigen receptor for enhanced anti-tumor effector functioning of T cells

Abstract

Integration of costimulatory signaling domains within a tumor targeting chimeric antigen receptor (CAR), such as the IL13Rα2 specific IL13-zetakine (IL13ζ), enhances T cell-mediated responses against tumors even in the absence of expressed ligands for costimulatory receptors.

Dependencies are inferred from the claim text.