Methods for generating databases and databases for identifying polymorphic genetic markers

A method for determining whether a polymorphism correlates with susceptibility to morbidity, early mortality, or morbidity and early mortality, comprising:

• identifying a polymorphism, wherein said polymorphism has not previously been correlated with susceptibility to morbidity, early mortality, or morbidity and early mortality;
• obtaining samples from healthy individuals within more than one age range;
• pooling the samples from healthy individuals within each age range, wherein healthy individuals are selected only on the basis of being healthy;
• determining the frequency of the identified polymorphism in each sample pool using mass spectrometry, which includes identifying the appearance or disappearance of the polymorphism with increasing age;
• and
• correlating said frequency of the appearance or disappearance of the polymorphism with increasing age in the healthy population with susceptibility to morbidity, early mortality, or morbidity and early mortality in said healthy population.