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US 8,818,733 B2Granted
Determination of photodynamic therapy (PDT) treatment parameters
AssigneesMayo Foundation for Medical Education and Research, College of Charleston
InventorsLinda R. Jones, Herbert C. Wolfsen, Michael B. Wallace, Nathan J. Towles, Fletcher B. Moore
Life of this patent
Estimating the term…
Abstract
A photodynamic therapy system and methods determine the amount (concentration) of a photosensitizer agent present in the target tissue. The system may also determine the tissue oxygenation. The system may also determine light dosimetry parameters based on the amount of photosensitizer in the tissue and/or the tissue oxygenation.
Claims20
A method comprising:
- illuminating target tissue of a patient containing a concentration of a photosensitizer with one or more wavelengths suitable for fluorescence excitation of the photosensitizer;
- detecting total emissions from the target tissue over a wavelength range of interest, the emissions including autofluorescence emissions of the target tissue and fluorescence emissions of the photosensitizer;
- determining the autofluorescence of the target tissue;
- generating a corrected photosensitizer emission by subtracting the autofluorescence emission from the total emissions from the target tissue;
- determining a photosensitizer content ratio based on the corrected photosensitizer emission and the autofluorescence of the target tissue;
- and
- determining the concentration of the photosensitizer in the target tissue based on the photosensitizer content ratio.
4 more elements
A non-transitory computer readable medium comprising instructions that cause a processor to:
- control illumination of target tissue of a patient containing a concentration of a photosensitizer with one or more wavelengths suitable for fluorescence excitation of the photosensitizer;
- receive total emissions from the target tissue over a wavelength range of interest, the emissions including autofluorescence emissions of the target tissue and fluorescence emissions of the photosensitizer;
- determine the autofluorescence of the target tissue;
- generate a corrected photosensitizer emission by subtracting the autofluorescence emission from the total emissions from the target tissue;
- determine a photosensitizer content ratio based on the corrected photosensitizer emission and the autofluorescence of the target tissue;
- and
- determine the concentration of the photosensitizer in the target tissue based on the photosensitizer content ratio.
4 more elements
A system, comprising:
- a light source that illuminates target tissue of a patient containing a concentration of a photosensitizer with one or more wavelengths suitable for fluorescence excitation of the photosensitizer;
- one or more detectors that detect total emissions from the target tissue over a wavelength range of interest, the emissions including autofluorescence emissions of the target tissue and fluorescence emissions of the photosensitizer;
- and
- a processor that receives the autofluorescence emissions and the total emissions, determines the autofluorescence of the target tissue, generates a corrected photosensitizer emission by subtracting the autofluorescence emission from the total emissions from the target tissue, determines a photosensitizer content ratio based on the corrected photosensitizer emission and the autofluorescence of the target tissue, and determines the concentration of the photosensitizer in the target tissue based on the photosensitizer content ratio.
1 more element
Dependencies are inferred from the claim text.