Molecular network analysis support method and apparatus

A molecular network analysis support apparatus comprising:

• a memory;
• and
• at least one processor connected with the memory, which
• receives, through a user input, a designated name of a biological phenomenon,
• extracts, from a molecular network including nodes representing molecules and edges between the nodes representing molecular interactions between the molecules, information indicating a type of molecular reaction,
• calculates, with reference to a first database storing information on a plurality of medical references, a first score and a second score, the first score being a ratio of a number of medical references of the plurality of medical references in which both the designated name of the biological phenomenon and the information indicating the type of molecular reaction appear for a molecular pair in relation to a number of medical references of the plurality of medical references in which the molecular pair appears, and the second score being a ratio of a number of medical references of the plurality of medical references in which both the designated name of the biological phenomenon and the information indicating the type of molecular reaction appear for all molecular pairs of the molecular network in relation to a number of medical references of the plurality of medical references in which all of the molecular pairs appear,
• calculates a value of a first relation strength for each interaction of the molecular pair in the molecular network based on an operation using ratios of the first score and the second score, each value of the first relation strength representing a strength of a relationship between the biological phenomenon identified by the designated name of the biological phenomenon and the type of molecular interaction for the molecular pair;
• and controls a display screen to display,
• the molecular network in which the value of the first relation strength for an interaction of the molecular pair is correlated with at least a corresponding edge and a corresponding node.

A non-transitory computer-readable recording medium storing therein a molecular network analysis support program that causes a computer to execute a process comprising:

• receiving, through a user input, a designated name of a biological phenomenon;
• extracting, from a molecular network including nodes representing molecules and edges between the nodes representing molecular interactions between the molecules, information indicating a type of molecular reaction;
• calculating, with reference to a first database storing information on a plurality of medical references, a first score and a second score, the first score being a ratio of a number of medical references of the plurality of medical references in which both the designated name of the biological phenomenon and the information indicating the type of molecular reaction appear for a molecular pair in relation to a number of medical references of the plurality of medical references in which the molecular pair appears, and the second score being a ratio of a number of medical references of the plurality of medical references in which both the designated name of the biological phenomenon and the information indicating the type of molecular reaction appear for all molecular pairs of the molecular network in relation to a number of medical references of the plurality of medical references in which all of the molecular pairs appear;
• calculating a value of a first relation strength for each interaction of the molecular pair in the molecular network based on an operation using ratios of the first score and the second score, each value of the first relation strength representing a strength of a relationship between the biological phenomenon identified by the designated name of the biological phenomenon and the type of molecular interaction for the molecular pair;
• and
• controlling a display screen to display the molecular network in which the value of the first relation strength for an interaction of the molecular pair is correlated with at least a corresponding edge and a corresponding node.