Baroreflex stimulation synchronized to circadian rhythm
AssigneeCardiac Pacemakers, Inc.
InventorImad Libbus
Life of this patent
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Abstract
An embodiment of a baroreflex stimulator comprises a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator to modulate the baroreflex stimulation signal based on a circadian rhythm template. According to an embodiment of a method for operating an implantable medical device, comprising a baroreflex stimulation therapy is applied at a stimulation intensity using a baroreflex stimulator in the implantable medical device, and the baroreflex stimulation therapy is modulated based on a circadian rhythm template stored within the implantable medical device. Modulating the baroreflex stimulation therapy includes using the circadian rhythm template to change the stimulation intensity to mimic natural blood pressure fluctuations during the day.
Claims23
An implantable medical system for treating a patient, the system comprising:
- a pulse generator configured to generate stimulation for a baroreflex therapy;
- a sensor configured to sense a physiologic parameter for monitoring a physiological response to the baroreflex therapy, wherein the pulse generator is configured to use the monitored physiological response to control generation of the stimulation for the baroreflex therapy to achieve a target physiological response to the baroreflex therapy;
- a circadian rhythm template storage with a circadian rhythm template stored therein, wherein the template reflects natural fluctuations throughout a day in the physiologic parameter;
- and
- a modulator configured to use the circadian rhythm template to change the target physiological response to the baroreflex stimulation therapy to mimic the natural fluctuations in the physiologic parameter of the patient throughout the day.
A method for delivering a baroreflex therapy, the method comprising:
- sensing a physiologic parameter for monitoring a physiological response to the baroreflex therapy;
- stimulating a neural stimulation target, based on the monitored physiological response, to achieve a target physiological response to the baroreflex therapy;
- and
- modulating the target physiological response to the baroreflex therapy, based on a circadian rhythm template that reflects natural fluctuations throughout a day in the physiologic parameter, to change the target physiological response to the baroreflex stimulation therapy to mimic the natural fluctuations in the physiologic parameter of the patient throughout the day.
Dependencies are inferred from the claim text.