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US 8,818,508 B2Granted
Dosing vagal nerve stimulation therapy in synchronization with transient effects
AssigneeMedtronic, Inc.
InventorAvram Scheiner
Life of this patent
Estimating the term…
Abstract
The present disclosure is directed to a method of using an implantable medical device. One embodiment of the present disclosure comprises delivering electrical stimulation proximate nerve tissue of a patient during a transient physiological effect period separated by a recovery period. The transient physiological effect period is when electrical stimulation has an increased level of efficacy and the recovery period is when additional electrical stimulation does not provide a beneficial physiological effect to the patient.
Claims22
A method of using an implantable medical device comprising:
- delivering electrical stimulation proximate nerve tissue of a patient during a transient physiological effect period separated by a recovery period, the transient physiological effect period is when electrical stimulation has an increased level of efficacy and the recovery period is when additional electrical stimulation does not provide a beneficial physiological effect to the patient;
- and
- determining an end of the recovery period by sending test electrical stimuli to the nerve tissue and monitoring for an effective response to the test electrical stimuli.
A method of using an implantable medical device comprising:
- delivering electrical stimulation proximate nerve tissue of a patient;
- determining a first physiological condition is higher than a target physiological condition;
- determining an end to a transient physiological effect period;
- ceasing electrical stimulation in response to determining the end of the transient physiological effect period;
- determining an end of a recovery period by sending test electrical stimuli to the nerve tissue and monitoring for an effective response to the test electrical stimuli;
- determining a second physiological condition is higher than the target physiological condition;
- and
- delivering automatically electrical stimulation proximate the nerve tissue in response to determining a second physiological condition is greater than the target physiological condition.
5 more elements
A method of using an implantable medical device comprising:
- determining a baseline heart rate;
- determining a target heart rate;
- determining a first heart rate is equal to or greater than the target heart rate;
- initiating electrical stimulation proximate vagal nerve tissue of the patient, in response to determining the first heart rate is equal to or greater than the target heart rate;
- determining a second heart rate is equal to or greater than the target heart in response to initiating electrical stimulation proximate vagal nerve tissue;
- determining an end to a transient physiological effect period in response to determining the second heart rate;
- ceasing electrical stimulation in response to determining the end of the transient physiological effect period;
- determining an end of a recovery period in response to ceasing delivery of the electrical stimulation by sending test electrical stimuli during the recovery period to the nerve tissue and monitoring for an effective response to the test electrical stimuli;
- determining a third heart rate is equal to or greater than the target heart rate in response to determining the end of the recovery period;
- and
- delivering automatically electrical stimulation proximate vagal nerve tissue of the patient, in response to determining a third heart rate is equal to or greater than the target heart rate.
8 more elements
A method of using an implantable medical device comprising:
- determining a first heart rate in a patient;
- delivering electrical stimulation proximate vagal nerve tissue of the patient until a predetermined second heart rate is attained during a transient effect period, the second heart rate is lower than the first heart rate;
- ceasing electrical stimulation in response to determining a second heart rate;
- determining an end of the recovery period by sending test electrical stimuli to the vagal nerve tissue and monitoring for an effective response to the test electrical stimuli;
- determining the heart rate starting to return to or completely returning to the first heart rate after determining the end of the recovery period;
- delivering automatically electrical stimulation proximate vagal nerve tissue of the patient after the recovery period has ended;
- and
- lowering the heart rate to the second heart rate.
5 more elements
A method of obtaining a target heart rate through use of an implantable medical device comprising:
- delivering electrical stimulation proximate vagal nerve tissue of a patient during a transient physiological effect period separated by a recovery period, the transient physiological effect period is when electrical stimulation has an increased level of efficacy and the recovery period is when additional electrical stimulation does not provide a beneficial physiological effect to the patient;
- and
- determining an end of the recovery period by sending test electrical stimuli to the nerve tissue and monitoring for an effective response to the test electrical stimuli.
A method of using an implantable medical device comprising:
- automatically delivering electrical stimulation proximate nerve tissue of a patient during a transient physiological effect period separated by a recovery period, the transient physiological effect period is when electrical stimulation has an increased level of efficacy in achieving a target physiological condition and the recovery period is when additional electrical stimulation does not provide a beneficial effect toward achieving the target physiological condition;
- determining during the transient physiological effect period and subsequent to achieving the beneficial effect if the target physiological condition is not met;
- ceasing the electrical stimulation in response to determining the target physiological condition is not met;
- determining an end of the recovery period by sending test electrical stimuli to the nerve tissue and monitoring for an effective response to the test electrical stimuli;
- determining if the target physiological condition is not met subsequent to determining the end of the recovery period;
- and
- delivering automatically electrical stimulation proximate the nerve tissue in response to determining the target physiological condition is not met subsequent to determining the end of the recovery period.
4 more elements
Dependencies are inferred from the claim text.