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US 8,816,122 B2Granted
Prostratin analogs, bryostatin analogs, prodrugs, synthetic methods, and methods of use
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsPaul A. Wender, Lars V. Heumann, Rainer Kramer, Carolyn Gauntlett, Elizabeth Mieuli, Dennis Fournogerakis, Pierre-Luc Boudreault, Adam Schrier, Brian DeChristopher
Life of this patent
Estimating the term…
Abstract
Embodiments of the present disclosure provide for prostratin analogs, bryostatin analogs, prodrugs of prostratin and prostratin analogs, methods of making prostratin analogs, and methods of making prodrugs of prostratin and prostratin analogs, methods of use of prostratin analogs, bryostatin analogs, and prodrugs thereof, and the like.
Claims7
A compound according to the formula:
- wherein X in each instance is independently selected from:
- O, S, and N;
- wherein R1 is a mono- or di-substituent, depending on X, selected from:
- H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted biaryl, substituted or unsubstituted fused aryl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl;
- wherein R2 is a mono- or di-substituent, depending on X, and is H;
- and
- wherein R3 is a mono- or di-substituent selected from:
- H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted biaryl, substituted or unsubstituted fused aryl, substituted or unsubstituted alkenyl, and substituted or unsubstituted alkynyl, alkoxy, acetoxy, phenyloxy, alkylthio, phenylthio, halogen, alkylamino, or diphenylamino,
- wherein when X in XR1 is 0, then R1 is —C(═O)CH2-FMA, or —C(═O)CH(CH3)-FMA, where FMA is selected from the group consisting of:
- an unsubstituted heteroaryl, substituted or unsubstituted fused aryl, substituted or unsubstituted cycloalkyl, and substituted or unsubstituted biaryl,
- or R1 is —C(═O)-FMA, then FMA is selected from the group consisting of:
- a substituted or unsubstituted heteroaryl, substituted or unsubstituted fused aryl, substituted cycloalkyl, and substituted or unsubstituted biaryl.
9 more elements
A compound according to Formula II described below:
- wherein R is selected from the group consisting of:
- substituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted biaryl, and substituted or unsubstituted fused aryl.
Dependencies are inferred from the claim text.