Polynucleotides encoding anti-CD100 antibodies or antigen-binding fragments thereof
AssigneeVaccinex, Inc.
InventorsErnest S. Smith, Terrence Lee Fisher
Life of this patent
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Abstract
Isolated polynucleotides are provided which encode antibody VH and VL polypeptides, and anti-CD100 antibodies and antigen-binding fragments thereof. In another aspect, the invention provides a vector comprising a polynucleotide of the invention. In another aspect, the invention provides a host cell comprising the vector of the invention. In another aspect, the invention provides a method of producing an antibody of the invention, e.g., for treating diseases associated with CD100, including certain autoimmune diseases, inflammatory diseases, and cancers.
Claims24
An isolated polynucleotide comprising a nucleotide sequence which encodes an antibody heavy chain variable region (VH) polypeptide comprising the amino acid sequence SEQ ID NO:
- 9;
- wherein an antibody comprising said VH polypeptide and a VL polypeptide comprising VL-CDR1, VL-CDR2, and VL-CDR3 amino acid sequences consisting of SEQ ID NOs:
- 14, 15, and 16, respectively, can specifically bind to CD100.
An isolated polynucleotide comprising a nucleotide sequence which encodes an antibody light chain variable region (VL) polypeptide comprising the amino acid sequence SEQ ID NO:
- 17;
- wherein an antibody comprising said VL polypeptide and a VH polypeptide comprising VH-CDR1, VH-CDR2, and VH-CDR3 amino acid sequences consisting of SEQ ID NOs:
- 6, 7, and 8, respectively, can specifically bind to CD100.
A composition comprising an isolated VH encoding polynucleotide and an isolated VL encoding polynucleotide, wherein said VH encoding polynucleotide comprises a cDNA that encodes a VH polypeptide comprising VH-CDR1, VH-CDR2, and VH-CDR3 amino acid sequences consisting of SEQ ID NOs:
- 6, 7, and 8, respectively;
- wherein said VL encoding polynucleotide comprises a cDNA that encodes a VL polypeptide comprising VL-CDR1, VL-CDR2, and VL-CDR3 amino acid sequences consisting of SEQ ID NOs:
- 14, 15, and 16, respectively;
- and wherein an antibody or fragment thereof encoded by said VH and VL encoding polynucleotides specifically binds CD100.
A recombinant host cell comprising a VH-encoding polynucleotide and a VL-encoding polynucleotide, wherein the VH-encoding polynucleotide encodes a VH polypeptide comprising VH-CDR1, VH-CDR2, and VH-CDR3 amino acid sequences consisting of SEQ ID NOs:
- 6, 7, and 8, respectively, wherein the VL-encoding polynucleotide encodes a VL polypeptide comprising VL-CDR1, VL-CDR2, and VL-CDR3 amino acid sequences consisting of SEQ ID NOs:
- 14, 15, and 16, respectively, wherein the VH encoding polynucleotide and the VL encoding polynucleotide are situated on separate vectors, and wherein an antibody or fragment thereof encoded by the VH and VL encoding polynucleotides specifically binds CD100.
Dependencies are inferred from the claim text.