Ionic silicone hydrogels having improved hydrolytic stability
AssigneeJohnson & Johnson Vision Care, Inc.
InventorsOsman Rathore, Zohra Fadli, Mark Lada, James D. Ford, Azaam Alli, Yongcheng Li
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Abstract
The present invention relates to ionic silicone hydrogel polymers displaying improved thermal stability. More specifically, the present invention relates to a polymer formed from reactive components comprising at least one silicone component and at least one ionic component comprising at least one anionic group. The polymers of the present invention display good thermal stability and desirable protein uptake.
Claims41
A contact lens formed by polymerizing components comprising at least one silicone component and at least one ionic component wherein said ionic component is present in said polymer in concentration between 0.2 and 0.8 wt %, wherein all silicone components are free of trimethyl silyl groups;
- and wherein said contact lens absorbs at least about 10 μg lysozyme, less than about 5 μg lipocalin and wherein at least about 50% of all proteins absorbed in or on said contact lens are in native form.
A contact lens formed by polymerizing components comprising at least one silicone component and at least one ionic component comprising at least one carboxylic acid group in molar concentrations up to about 9.3 mmol/100 gm, wherein all silicone components are free of trimethyl silyl groups, and wherein said contact lens absorbs at least about 10 μg lysozyme, less than about 5 μg lipocalin and wherein at least about 50% of proteins absorbed in or on said contact lens are in native form.
Dependencies are inferred from the claim text.