Substituted 4-(selenophen-2(or-3)-ylamino)pyrimidine compounds and methods of use thereof

A selenophene compound of formula (I), a salt thereof, a solvate or hydrate thereof, or a stereoisomer thereof:

• wherein:
• ring A is a 6-membered aromatic fused ring, optionally containing one, two or three nitrogen atoms;
• a 5-membered heteroaromatic fused ring containing at least one heteroatom selected from the group consisting of sulfur, oxygen, nitrogen and selenium, with the proviso that no more than one oxygen or sulfur or selenium atom is present;
• or a mono- or bicyclic saturated heterocyclic fused ring having 3 to 10 carbon atoms and at least one ring member selected from the group consisting of N, O, S, SO and SO2;
• wherein ring A is optionally substituted by at least one group independently selected from the group consisting of hydrogen, halogen, hydroxy, formyl, carboxylic acid, amino, nitro, cyano, sulfonic acid, thiole, trihalomethyl, sulfonamide, C1-6alkyl, C1-6secondary-alkyl, C1-6tertiary-alkyl, C2-6alkenyl, C2-6alkynyl, C1-4alkylcarbonyl, C1-4alkoxycarbonyl, aminocarbonyl, C1-6alkylaminocarbonyl, di(C1-6alkyl)aminocarbonyl, haloC1-6alkyl, hydroxyC1-6alkyl, C1-6alkoxy, haloC1-6alkoxy, hydroxyC1-6alkoxy, C3-7cycloalkyl, C3-7cycloalkoxy, C1-6alkylamino, di(C1-6alkyl)amino, aminoC1-6alkyl, aminoC1-6alkoxy, C1-6alkylaminoC1-6alkyl, di(C1-6alkyl)aminoC1-6alkyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, and a aryl, heteroaryl and heterocycloalkyl ring;
• aryl, heteroaryl and heterocycloalkyl ring optionally substituted by halogen, hydroxy, formyl, carboxylic acid, amino, nitro, cyano, sulfonic acid, thiole, trihalomethyl, sulfonamide, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-4alkylcarbonyl, C1-4-alkoxycarbonyl, aminocarbonyl, C1-6alkylaminocarbonyl, di(C1-6alkyl)aminocarbonyl, haloC1-6alkyl, hydroxyC1-6alkyl, C1-6alkoxy, haloC1-6alkoxy, hydroxyC1-6alkoxy, C3-7cycloalkyl, C3-7cycloalkoxy, C1-6alkylamino, di(C1-6alkyl)amino, aminoC1-6alkyl, aminoC1-6alkoxy, C1-6alkylaminoC1-6alkyl, di(C1-6alkyl)aminoC1-6alkyl, C1-6alkylsulfinyl, and C1-6alkylsulfonyl;
• Y in ring B is N or C—R5, wherein R5 is selected from hydrogen, halogen, hydroxy, formyl, carboxylic acid, amino, nitro, cyano, sulfonic acid, thiole, trihalomethyl, sulfonamide, C1-6alkyl, C1-6secondary-alkyl, C1-6tertiary-alkyl, C2-6alkenyl, C2-6alkynyl, C1-4alkylcarbonyl, C1-4alkoxycarbonyl, aminocarbonyl, C1-6alkylaminocarbonyl, di(C1-6alkyl)aminocarbonyl, haloC1-6alkyl, hydroxyC1-6alkyl, C1-6alkoxy, haloC1-6alkoxy, hydroxyC1-6alkoxy, C3-7cycloalkyl, C3-7cycloalkoxy, C1-6alkylamino, di(C1-6alkyl)amino, aminoC1-6alkyl, aminoC1-6alkoxy, C1-6alkylaminoC1-6alkyl, di(C1-6alkyl)aminoC1-6alkyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl;
• X is attached to the C2 carbon of the selenophene ring or to the C3 carbon of the seleneophene ring, and X is selected from the group consisting of NR6, O, S, S(O), and S(O)2;
• wherein R6 is selected from hydrogen, amino, C1-6alkyl, and haloC1-6alkyl;
• R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, hydroxy, formyl, carboxylic acid, amino, nitro, cyano, sulfonic acid, thiole, trihalomethyl, sulfonamide, C1-6alkyl, C1-6secondary-alkyl, C1-6tertiary-alkyl, C2-6alkenyl, C2-6alkynyl, C1-4alkylcarbonyl, C1-4alkoxycarbonyl, aminocarbonyl, C1-6alkylaminocarbonyl, di(C1-6alkyl)aminocarbonyl, haloC1-6alkyl, hydroxyC1-6alkyl, C1-6alkoxy, haloC1-6alkoxy, hydroxyC1-6alkoxy, C3-7cycloalkyl, C3-7cycloalkoxy, C1-6alkylamino, di(C1-6alkyl)amino, aminoC1-6alkyl, amino C1-6alkoxy, C1-6alkyl amino C1-6alkyl, di(C1-6alkyl)amino C1-6alkyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, and a aryl, heteroaryl and heterocycloalkyl ring;
• aryl, heteroaryl and heterocycloalkyl ring optionally substituted by halogen, hydroxy, formyl, carboxylic acid, amino, nitro, cyano, sulfonic acid, thiole, trihalomethyl, sulfonamide, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-4alkylcarbonyl, C1-4alkoxycarbonyl, aminocarbonyl, C1-6alkylaminocarbonyl, di(C1-6alkyl)aminocarbonyl, haloC1-6alkyl, hydroxyC1-6alkyl, C1-6alkoxy, haloC1-6alkoxy, hydroxyC1-6alkoxy, C3-7cycloalkyl, C3-7cycloalkoxy, C1-6alkylamino, di(C1-6alkyl)amino, aminoC1-6alkyl, aminoC1-6alkoxy, C1-6alkylaminoC1-6alkyl, di(C1-6alkyl)aminoC1-6alkyl, C1-6alkylsulfinyl, and C1-6alkylsulfonyl.