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US 8,815,824 B2Granted
Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis
AssigneeTechnion Research & Development Foundation Limited
InventorGera Neufeld
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Abstract
The present disclosure provides pharmaceutical compositions and methods useful for modulating angiogenesis and for inhibiting metastasis, tumors, pulmonary alveolar proteinosis, and fibrosis in a mammalian tissue. Pharmaceutical compositions and methods include inhibitors of LOXL2 expression and activity, such as shRNA targeting LOXL2.
Claims12
A method for inhibiting fibrosis, tumor growth, or tumor metastasis, in a subject, the method comprising:
- administering a polynucleotide to the subject, thereby inhibiting fibrosis, tumor growth, or tumor metastasis, wherein the tumor is breast adenocarcinoma, fibrosarcoma or melanoma, wherein the polynucleotide comprises:
- a first sequence comprising a nucleic acid sequence of SEQ ID NO:
- 20 or SEQ ID NO:
- 21,
- a second sequence comprising a region of complementarity to the nucleic acid sequence of SEQ ID NO:
- 20 or SEQ ID NO:
- 21, wherein the region of complementarity is at least 19 bases in length, and
- a linking sequence that joins the first sequence to the second sequence,
- wherein the polynucleotide forms a hairpin-loop structure having a double-stranded stem region of between 19 and 21 base pairs in length that comprises the region of complementarity, wherein ends of the double-stranded stem region are connected by the linking sequence.
6 more elements
Dependencies are inferred from the claim text.