Process for producing a composition containing active follistatin
AssigneeMyos Corp.
InventorsWaldemar Buxmann, Volker Heinz, Stefan Toepfl
Life of this patent
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Abstract
A process for producing a composition containing biologically active follistatin from a biological source, which composition is preserved and, especially pathogen free and is storage stable, preferably at room temperature. Further, the invention relates to the composition containing biologically active follistatin, which composition is available by the production process. The invention provides a process for producing a composition containing biologically active follistatin from avian eggs, or from raw animal blood serum.
Claims26
A process for producing a composition comprising biologically active follistatin, the process comprising:
- providing raw liquid egg yolk, raw liquid whole egg or raw liquid egg white originating from fertilized avian eggs and subjecting the raw liquid egg yolk, raw liquid whole egg or raw liquid egg white to a step of preservation while maintaining the temperature at or below 38° C., wherein the step of preservation is selected from subjecting the raw liquid egg yolk, raw liquid whole egg or raw liquid egg white to a high pressure treatment of at least 4500 bar for at least 1 min, from subjecting the raw liquid egg yolk, raw liquid whole egg or raw liquid egg white to a pulsed electric field treatment of at least 5 kV/cm at a flow rate of 30 L/h, and from a combination of the high pressure treatment and the pulsed electric field treatment to provide a preserved liquid egg yolk, preserved liquid whole egg or preserved liquid egg white.
A process for producing a composition comprising biologically active follistatin, the process comprising:
- providing raw animal blood serum and subjecting the raw animal blood serum to a step of preservation while maintaining the temperature at or below 38° C., wherein the step of preservation consists of filling the raw liquid animal blood into containers, sealing the containers and subjecting the raw animal blood serum to a high pressure treatment of at least 4500 bar for at least 1 min.
A process for producing a composition comprising biologically active follistatin, the process comprising:
- providing raw liquid egg yolk, raw liquid whole egg or raw liquid egg white originating from fertilized avian eggs and subjecting the raw liquid egg yolk, raw liquid whole egg or raw liquid egg white to a step of preservation while maintaining the temperature at or below 38° C., wherein the step of preservation is selected from subjecting the raw liquid egg yolk, raw liquid whole egg or raw liquid egg white to a high pressure treatment of at least 4500 bar for at least 1 min, from subjecting the raw liquid egg yolk, raw liquid whole egg or raw liquid egg white to a pulsed electric field treatment of at least 5 kV/cm at a flow rate of 30 L/h, and from a combination of the high pressure treatment and the pulsed electric field treatment to provide a preserved liquid egg yolk, preserved liquid whole egg or preserved liquid egg white, wherein the preserved liquid egg yolk, preserved liquid whole egg or preserved liquid egg white is dried by freeze-drying or by fluidized bed drying.
A process for producing a composition comprising biologically active follistatin, the process comprising:
- providing raw liquid egg yolk, raw liquid whole raw liquid egg or raw liquid egg white originating from fertilized avian eggs and subjecting the raw liquid egg yolk, raw liquid whole egg or raw liquid egg white to a step of preservation while maintaining the temperature at or below 38° C., wherein the raw liquid egg yolk, raw liquid whole egg or raw liquid egg white which is filled into containers, the containers are sealed and subjected to the high pressure treatment of at least 4500 bar for at least 1 min to provide a preserved liquid egg yolk, preserved liquid whole egg or preserved liquid egg white, wherein the preserved liquid egg yolk, preserved liquid whole egg or preserved liquid egg white is dried by freeze-drying, wherein between the step of high pressure treatment and the step of freeze-drying, the preserved liquid egg yolk, preserved liquid whole egg or preserved liquid egg white is transported in the sealed containers in which the raw liquid egg yolk, raw liquid whole egg or raw liquid egg white was subjected to the high pressure treatment.
Dependencies are inferred from the claim text.