Compounds, compositions, and methods for control of hepatitis C viral infections
AssigneeApath, LLC
InventorsUrszula Slomczynska, Paul Olivo, Jodi Beattie, Gale Starkey, Amine Noueiry, Robert Roth
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Abstract
Various tetrahydropyrazolo[1,5-a]pyrimidine compounds, compositions, methods of making, and methods for the prevention and treatment of HCV infections and associated diseases are disclosed. The invention further relates to biomarkers for identification of HCV strains which are resistant to the tetrahydropyrazolo[1,5-a]pyrimidine compounds.
Claims6
A method of treating a hepatitis C viral infection in a subject in need thereof, said method comprising administering to said subject a pharmaceutical composition that comprises a therapeutically effective amount of an enantiomer that inhibits hepatitis C viral replication having the formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from the group consisting of unsubstituted thienyl-2 and unsubstituted furyl-2;
- R2 is selected from the group consisting of —CCl3, —CBr3, and —CF3;
- R3 is —CONHR″3, wherein R″3 is meta-hydroxyalkyl substituted phenyl, or —(X)—R, wherein X is —(CH2)n—, wherein n is 1 or 2, and wherein R is a unsubstituted thienyl-2 and unsubstituted furyl-2 group;
- R4 is selected from the group consisting of hydrogen, chloro, bromo, and fluoro;
- and wherein said compound or salt thereof is an enantiomer with R1 and R2 in a syn configuration that inhibits hepatitis C viral replication,
- thereby treating said hepatitis C viral infection in said subject.
Dependencies are inferred from the claim text.