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AssigneesTokyo Metropolitan Institute of Medical Science, Renascience Co., Ltd.
InventorsMasanari Itokawa, Toshio Miyata, Makoto Arai
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The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia contains a carbonyl scavenger or a carbonyl-modified protein formation inhibitor as an active ingredient. The method for diagnosing schizophrenia according to the present invention includes measuring at least one parameter in a subject, the parameter being selected from the group consisting of: (1) a genetic abnormality of glyoxalase I gene; (2) the expression level or activity of glyoxalase I in a biological sample; (3) the amount of a carbonyl compound or a carbonyl-modified protein that is a protein modified with the carbonyl compound; and (4) the amount of pyridoxal in a biological sample.
A method for treating or ameliorating schizophrenia in a warm-blooded animal having schizophrenia, comprising administering a preparation comprising a pharmaceutically effective amount of pyridoxamine, or a pharmaceutically acceptable salt or ester thereof having a carbonyl scavenger effect, as an active ingredient to the warm-blooded animal having schizophrenia.
A method for treating or ameliorating schizophrenia in a warm-blooded animal having schizophrenia, comprising administering a preparation containing a pharmaceutically effective amount of pyridoxamine, or a pharmaceutically acceptable salt or ester thereof having a carbonyl scavenger effect, as the sole active ingredient for ameliorating schizophrenia to the warm-blooded animal having schizophrenia.
Dependencies are inferred from the claim text.