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US 8,808,786 B2Granted
Medicinal inhalation devices and components thereof
Assignee3M Innovative Properties Company
InventorsPhilip A. Jinks, Moses M. David, Rudolf J. Dams
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Assignee3M Innovative Properties Company
InventorsPhilip A. Jinks, Moses M. David, Rudolf J. Dams
Estimating the term…
Medicinal inhalation devices and components having a non-metal coating and a fluorine-containing coating bonded to the non-metal coating wherein the fluorine-containing coating comprises an at least partially fluorinated compound comprising at least one functional group which shares at least one covalent bond with the non-metal coating are provided. In some embodiments, the partially fluorinated compound comprises a polyfluoropolyether silane of Formula Ia: Rf[Q-[C(R)2—Si(Y)3-x(R1a)x]y]z Ia wherein: Rf is a monovalent or multivalent polyfluoropolyether segment; Q is an organic divalent or trivalent linking group; each R is independently hydrogen or a C1-4 alkyl group; each Y is independently a hydrolysable group; R1a is a C1-8 alkyl or phenyl group; x is 0 or 1 or 2; y is 1 or 2; and z is 1, 2, 3, or 4. Methods of making the devices and components are also provided.
A method of making a medicinal inhalation device comprising:
A medicinal inhalation device comprising a non-metal coating on at least a portion of a surface of the device and a fluorine-containing coating bonded to the non-metal coating wherein the fluorine-containing coating comprises an at least partially fluorinated compound comprising at least one functional group which shares at least one covalent bond with the non-metal coating, where said surface of the device is a surface that is or will come in contact with a medicament or a medicinal formulation during storage or delivery from the medicinal inhalation device.
A medicinal inhalation device comprising a non-metal coating on at least a portion of a surface of the device and a fluorine-containing coating bonded to the non-metal coating wherein the fluorine-containing coating comprises an at least partially fluorinated compound comprising at least one functional group which shares at least one covalent bond with the non-metal coating, wherein the device is a metered dose inhaler and the inhaler contains a medicinal aerosol formulation comprising a medicament and HFA 134a and/or HFA 227.
A component of a medicinal inhalation device comprising a non-metal coating on at least a portion of a surface of the component, and a fluorine-containing coating bonded to the non-metal coating wherein the fluorine-containing coating comprises an at least partially fluorinated compound comprising at least one functional group which shares at least one covalent bond with the non-metal coating, where said surface of the component of the device is a surface that is or will come in contact with a medicament or a medicinal formulation during storage or delivery from the medicinal inhalation device.
A component of a medicinal inhalation device comprising a non-metal coating on at least a portion of a surface of the component, and a fluorine-containing coating bonded to the non-metal coating wherein the fluorine-containing coating comprises an at least partially fluorinated compound comprising at least one functional group which shares at least one covalent bond with the non-metal coating, wherein the component is a component of a metered dose inhaler and the component is selected from the group consisting of an actuator, an aerosol container, a ferrule, a valve body, a valve stem and a compression spring.
A component of a medicinal inhalation device comprising a non-metal coating on at least a portion of a surface of the component, and a fluorine-containing coating bonded to the non-metal coating wherein the fluorine-containing coating comprises an at least partially fluorinated compound comprising at least one functional group which shares at least one covalent bond with the non-metal coating, wherein the component is a component of a dry powder inhaler and the component is selected from the group consisting of a powder container, a component used to open a sealed powder container, a component that defines at least in part a deagglomeration chamber, a component of a deaglomeration system, a component that defines at least in part a flow channel, a dose-transporting component, a component that defines at least in part a mixing chamber, a component that defines at least in part an actuation chamber, a mouthpiece and a nosepiece.
A component of a medicinal inhalation device comprising a non-metal coating on at least a portion of a surface of the component, and a fluorine-containing coating bonded to the non-metal coating wherein the fluorine-containing coating comprises an at least partially fluorinated compound comprising at least one functional group which shares at least one covalent bond with the non-metal coating, wherein the component is a component of a breath-actuating device or a component of a breath-coordinating device or a spacer or a component of a spacer or a component of a dose counter for a medicinal inhalation device.
Dependencies are inferred from the claim text.