Arthrospira-based compositions and uses thereof
AssigneeBiovite Australia Pty Ltd
InventorsKelvin Winston Duncan, Peter Owen Johnston, Ashley Michael Brown
Life of this patent
Estimating the term…
Abstract
The present invention concerns a composition comprising physiologically stressed Arthrospira maxima for use as a biocide and/or therapeutic. The invention also concerns a method for preventing or treating an infection or infestation of a subject by an organism, wherein the method comprises the step of administering to the subject an effective amount of a composition comprising physiologically stressed Arthrospira.
Claims24
A method for preparing a topical Arthrospira-based composition, said method comprising the steps of:
- (1) growing Arthrospira;
- (2) as a separate step, physiologically stressing the Arthrospira by a stressing technique selected from the group consisting of:
- depriving nutrients, depriving light, dehydrating and removing up to 80% of liquid within which the Arthrospira is being grown until substantially all of the Arthrospira enters an anabiotic state, but not freeze drying the Arthrospira, and obtaining stressed Arthrospira;
- and
- (3) combining a fungicidally or bactericidally effective amount of the stressed Arthrospira with a carrier, a solvent, a base or an excipient suitable for topical administration to the subject to form a the topical Arthrospira-based composition comprising at least 0.01% weight/weight stressed Arthrospira, and wherein the stressed Arthrospira of the composition comprises a filament material selected from the group consisting of:
- intact Arthrospira filaments, segments of Arthrospira filaments and disrupted Arthrospira filaments.
A method for preparing a topical fungicide or bactericide Arthrospira-based composition, said method comprising the steps of:
- (1) growing Arthrospira;
- (2) as a separate step, physiologically stressing the Arthrospira by removing up to about 80% of liquid within which the Arthrospira is being grown until substantially all of the Arthrospira enters an anabiotic state;
- (3) washing the stressed Arthrospira of step (2) in order to remove contaminants;
- (4) drying the washed Arthrospira of step (3);
- and to obtain a dried stressed Arthrospira, wherein the Arthrospira has not been freeze dried
- (5) combining a fungicidally or bactericidally effective amount of the dried stressed Arthrospira with a carrier, a solvent, a base or an excipient suitable for topical administration to a subject to form a the topical Arthrospira-based composition comprising at least 5% weight/weight stressed Arthrospira, and wherein the Arthrospira of the composition comprises a filament material selected from the group consisting of:
- intact Arthrospira filaments, segments of Arthrospira filaments and disrupted Arthrospira filaments.
A topical Arthrospira-based composition comprising a fungicidally effective amount of physiologically stressed Arthrospira, which is in an anabiotic state, and a carrier, a solvent, a base or an excipient suitable for topical administration, wherein the composition comprises at least 0.01% weight/weight stressed Arthrospira, wherein the physiological stressing is induced by a stressing technique selected from the group consisting of:
- depriving nutrients, depriving light, dehydrating, and removing up to 80% of liquid within which the Arthrospira is being grown until substantially all of the Arthrospira enters the anabiotic state wherein the Arthrospira has not been freeze dried, and wherein the stressed Arthrospira of the composition comprises a filament material selected from the group consisting of:
- intact Arthrospira filaments, segments of Arthrospira filaments and disrupted Arthrospira filaments.
A method for preventing or treating a topical fungal infection or infestation of a subject, said method comprising the step of topically administering to the subject a composition comprising a fungicidally effective amount of physiologically stressed Arthrospira, which is in an anabiotic state, and a carrier, a solvent, a base or an excipient suitable for topical administration to a subject, wherein the composition comprises at least 0.5% weight/weight stressed Arthrospira, wherein the physiological stressing is induced by a stressing technique selected from the group consisting of:
- depriving nutrients, depriving light, dehydrating, and removing up to 80% of liquid within which the Arthrospira is being grown until substantially all of the Arthrospira enters the anabiotic state wherein the Arthrospira has not been freeze dried and wherein the stressed Arthrospira of the composition comprises a filament material selected from the group consisting of:
- intact Arthrospira filaments, segments of Arthrospira filaments and disrupted Arthrospira filaments.
A method for preparing a topical fungicidal Arthrospira-based composition, said method comprising the steps of:
- (1) growing Arthrospira;
- (2) as a separate step, physiologically stressing the Arthrospira by a stressing technique selected from the group consisting of:
- depriving nutrients, depriving light, dehydrating, and removing up to 80% of liquid within which the Arthrospira is being grown until substantially all of the Arthrospira enters an anabiotic state, wherein the Arthrospira has not been freeze dried;
- and
- (3) combining a fungicidally effective amount of the stressed Arthrospira with a carrier, a solvent, a base or an excipient suitable for topical administration to a subject to form the topical fungicidal Arthrospira-based composition comprising at least 5% weight/weight stressed Arthrospira, and wherein the stressed Arthrospira of the composition comprises a filament material selected from the group consisting of:
- intact Arthrospira filaments, segments of Arthrospira filaments and disrupted Arthrospira filaments.
A topical fungicidal Arthrospira-based composition comprising:
- a combination of physiologically stressed Arthrospira, which is in an anabiotic state, at least one fungi-static agent, and a carrier, a solvent, a base or an excipient suitable for topical administration, wherein the composition comprises at least 0.01% weight/weight stressed Arthrospira, wherein the physiological stressing is induced by a stressing technique selected from the group consisting of:
- depriving nutrients, depriving light, dehydrating, and removing up to 80% of liquid within which the Arthrospira is being grown until substantially all of the Arthrospira enters the anabiotic state wherein the Arthrospira has not been freeze dried, and wherein the stressed Arthrospira of the composition comprises a filament material selected from the group consisting of:
- intact Arthrospira filaments, segments of Arthrospira filaments and disrupted Arthrospira filaments.
A method for preventing or treating a topical fungal infection or infestation of a subject, said method comprising the step of:
- topically administering to the subject a composition comprising a fungicidally effective amount of physiologically stressed Arthrospira, which is in an anabiotic state, at least one fungi-static agent, and a carrier, a solvent, a base or an excipient suitable for topical administration to a subject, wherein the composition comprises at least 5% weight/weight stressed Arthrospira, wherein the physiological stressing is induced using a stressing technique selected from the group consisting of:
- depriving nutrients, depriving light, dehydrating, and removing up to 80% of liquid within which the Arthrospira is being grown until substantially all of the Arthrospira enters the anabiotic state wherein the Arthrospira has not been freeze dried and wherein the stressed Arthrospira of the composition comprises a filament material selected from the group consisting of:
- intact Arthrospira filaments, segments of Arthrospira filaments and disrupted Arthrospira filaments.
A topical bactericidal Arthrospira-based composition comprising:
- a bactericidally effective amount of physiologically stressed Arthrospira, which is in an anabiotic state, and a carrier, a solvent, a base or an excipient suitable for topical administration to a subject, wherein the composition comprises at least 5% weight/weight stressed Arthrospira, wherein the physiological stressing is induced by a stressing technique selected from the group consisting of:
- depriving nutrients, depriving light, dehydrating, and removing up to 80% of liquid within which the Arthrospira is being grown until substantially all of the Arthrospira enters the anabiotic state wherein the Arthrospira has not been freeze dried, and wherein the stressed Arthrospira of the composition comprises a filament material selected from the group consisting of:
- intact Arthrospira filaments, segments of Arthrospira filaments and disrupted Arthrospira filaments.
A method for preventing or treating a topical bacterial infection or infestation of a subject, said method comprising:
- topically administering to the subject a composition comprising a bactericidally effective amount of physiologically stressed Arthrospira, which is in an anabiotic state, and a carrier, a solvent, a base or an excipient suitable for topical administration to a subject, wherein the composition comprises at least 5% weight/weight stressed Arthrospira, wherein the physiological stressing is induced by a stressing technique selected from the group consisting of:
- depriving nutrients, depriving light, dehydrating, and removing up to 80% of liquid within which the Arthrospira is being grown until substantially all of the Arthrospira enters the anabiotic state wherein the Arthrospira has not been freeze dried, and wherein the stressed Arthrospira of the composition comprises a filament material selected from the group consisting of:
- intact Arthrospira filaments, segments of Arthrospira filaments and disrupted Arthrospira filaments.
A method for preparing a topical bactericidal Arthrospira-based composition, said method comprising the steps of:
- (1) growing Arthrospira;
- (2) as a separate step, physiologically stressing the Arthrospira by a stressing technique selected from the group consisting of:
- depriving nutrients, depriving light, dehydrating, and removing up to 80% of liquid within which the Arthrospira is being grown until substantially all of the Arthrospira enters an anabiotic state to obtain a dried stressed Arthrospira, wherein the Arthrospira has not been freeze dried;
- and
- (3) combining a bactericidally effective amount of the stressed Arthrospira with a carrier, a solvent, a base or an excipient suitable for topical administration to a subject to form the topical bactericidal Arthrospira-based composition comprising at least 5% weight/weight stressed Arthrospira, and wherein the stressed Arthrospira of the composition comprises a filament material selected from the group consisting of:
- intact Arthrospira filaments, segments of Arthrospira filaments and disrupted Arthrospira filaments.
A topical Arthrospira-based composition for treating a defect of the skin of a mammal, said composition comprising:
- a fungicidally or bactericidally effective amount of physiologically stressed Arthrospira, which is in an anabiotic state, and a carrier, a solvent, a base or an excipient suitable for topical administration to a subject, wherein the composition comprises at least 5% weight/weight stressed Arthrospira, wherein the physiological stressing is induced by a stressing technique selected from the group consisting of:
- depriving nutrients, depriving light, dehydrating, and removing up to 80% of liquid within which the Arthrospira is being grown until substantially all of the Arthrospira enters the anabiotic state, wherein the Arthrospira has not been freeze dried, and wherein the stressed Arthrospira of the composition comprises a filament material selected from the group consisting of:
- intact Arthrospira filaments, segments of Arthrospira filaments and disrupted Arthrospira filaments.
A method of treating a defect of the skin of a mammal, said method comprising the step of topically administering to the mammal a composition comprising:
- a fungicidally or bactericidally effective amount of physiologically stressed Arthrospira, which is in an anabiotic state, and a carrier, a solvent, a base or an excipient suitable for topical administration to a subject, wherein the composition comprises at least 5% weight/weight stressed Arthrospira, wherein the physiological stressing is induced by a stressing technique selected from the group consisting of:
- depriving nutrients, depriving light, dehydrating, and removing up to 80% of liquid within which the Arthrospira is being grown until substantially all of the Arthrospira enters the anabiotic state wherein the Arthrospira has not been freeze dried, and wherein the stressed Arthrospira of the composition comprises a filament material selected from the group consisting of:
- intact Arthrospira filaments, segments of Arthrospira filaments and disrupted Arthrospira filaments.
Dependencies are inferred from the claim text.