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US 8,805,620 B2Granted
Method and system for selecting a donor or reproductive partner for a potential parent
AssigneeGenePeeks, Inc.
InventorLee M. Silver
Life of this patent
Estimating the term…
Abstract
Methods and systems for assessing the probabilities of the expression of one or more traits in progeny are described.
Claims16
A method of selecting a donor or reproductive partner for a potential parent from a pool of sperm donors, or from a pool of oocyte donors or from a pool of potential reproductive partners, the method implemented by a computer processor executing program instructions, the method comprising the steps of:
- (a) using the processor, generating a recipient haplopath Hirecipient={h1, h2, . . . , hN} including a single allele hx∈(1,2) of a genotype at each of a plurality of loci (1, . . . , N) from a recipient genome profile of a potential parent;
- (b) using the processor, generating a donor haplopath Hidonor={h1, h2, . . . , hN} including a single allele hx∈(1,2) of a genotype at each of the plurality of loci x=1, . . . , N from a donor genome profile of a member of a pool of sperm donors, oocyte donors or potential reproductive partners;
- (c) using the processor, combining said recipient haplopath Hirecipient with said donor haplopath Hidonor to generate a virtual progeny genome sampling
- G
- i
- VP
- =
- {
- [
- h
- x
- recipient
- h
- x
- donor
- ]
- }
- including two alleles hxrecipient and hxdonor of a genotype at each of the plurality of loci x=1, . . . , N for a potential progeny;
- (d) using the processor, comparing genotypes of said virtual progeny genome sampling to one or more databases of genotype-phenotype associations to determine a likelihood of expression of one or more phenotypes for the potential progeny having said virtual progeny genome sampling;
- and
- (e) repeating steps (a)-(d) for a plurality of recipient and donor haplopaths from, respectively, the recipient and donor potential parents i=1, . . . ,p to generate a virtual progeny genome GVP including a plurality of the virtual progeny genome samplings GVP=G1VP, G2VP, . . . , GpVP);
- (f) generating probabilities or probability distributions for said potential progeny expressing said one or more phenotypes based on the likelihoods determined for the plurality of virtual progeny genome samplings in the virtual progeny genome GVP;
- and
- (g) repeating steps (a)-(f) for each member of said pool of sperm donors, oocyte donors or potential reproductive partners.
21 more elements
A system for selecting a donor or reproductive partner for a potential parent from a pool of sperm donors, or from a pool of oocyte donors or from a pool of potential reproductive partners, the system comprising:
- a memory;
- and
- a computer processor to:
- (a) generate a recipient haplopath Hirecipient={h1, h2, . . . , hN} including a single allele hx∈(1,2) of a genotype at each of a plurality of loci (1, . . . , N) from a recipient genome profile of a potential parent;
- (b) generate a donor haplopath Hidonor={h1, h2, . . . , hN} including a single allele hx∈(1,2) of a genotype at each of the plurality of loci x=1, . . . , N from a donor genome profile of a member of a pool of sperm donors, oocyte donors or potential reproductive partners;
- (c) combine said recipient haplopath Hirecipient with said donor haplopath Hidonor to generate a virtual progeny genome sampling
- G
- i
- VP
- =
- {
- [
- h
- x
- recipient
- h
- x
- donor
- ]
- }
- including two alleles hxrecipient and hxdonor of a genotype at each of the plurality of loci x=1, . . . , N for a potential progeny;
- (d) compare genotypes of said virtual progeny genome sampling to one or more databases of genotype-phenotype associations to determine a likelihood of expression of one or more phenotypes for the potential progeny having said virtual progeny genome sampling;
- and
- (e) repeat steps (a)-(d) for a plurality of recipient and donor haplopaths from, respectively, the recipient and donor potential parents i=1, . . . , p to generate a virtual progeny genome GVP including a plurality of the virtual progeny genome samplings GVP={G1VP, G2VP, . . . , GpVP};
- (f) generate probabilities or probability distributions for said potential progeny expressing said one or more phenotypes based on the likelihoods determined for the plurality of virtual progeny genome samplings in the virtual progeny genome GVP;
- and
- (g) repeat steps (a)-(f) for each member of said pool of sperm donors, oocyte donors or potential reproductive partners.
24 more elements
Dependencies are inferred from the claim text.