System and method for cardiac resynchronization therapy control parameter generation using ventricular activation simulation and surface ECG registration

A cardiac implantable electrical device for delivering cardiac resynchronization therapy to a patient's heart, the cardiac implantable electrical device comprising:

• an input for receiving signals indicative of baseline cardiac electrical activity in the heart from electrocardiography surface leads;
• an impulse delivery system for delivering electrical impulses to the heart in order to provide cardiac resynchronization therapy thereto;
• a memory for storing pacing control parameters;
• a processor in communication with the memory, the processor being configured to:
• receive the received signals representing baseline cardiac electrical activity in the patient's heart;
• form a baseline model of ventricular conduction using the received signals;
• iteratively modify the baseline model to minimize ventricular electrical asynchrony;
• generate an updated model of global ventricular conduction that is indicative of ventricular activation wavefront fusion using the iteratively modified baseline model;
• convert the updated model into pacing control parameters using a QRS hieroglyph morphological framework;
• and
• communicate with the impulse delivery system to provide cardiac resynchronization therapy to the heart in accordance with the pacing control parameters.