Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device

A system comprising:

• a prediction criteria module, adapted to store information about one or more chronobiological rhythm prediction criteria;
• a physiological information collection device, adapted to sense or receive infbrmation about at least one physiological process having a chronobiological rhythm whose presence, absence, or change is statistically associated with a disease state;
• an impending disease state prediction module, coupled to the prediction criteria module to receive the one or more chronobiological rhythm prediction criteria and coupled to the physiological information collection device to receive the chronobiological rhythm of the at least one physiological process, the impending disease state prediction module being adapted to predict an occurrence of impending disease using the one or more chronobiological rhythm prediction criteria and the chronobiological rhythm of the at least one physiological process;
• and
• a therapy control module adapted to adjust or initiate a therapy using the predicted occurrence of impending disease, wherein the system is configured to monitor the efficacy of the therapy and to adjust the therapy to prevent or minimize the impending disease state.