Method and apparatus for delivering combined electrical and drug therapies

A cardiac rhythm management (CRM) system, comprising:

• an implantable pulse generator to deliver electrical pulses, the implantable pulse generator including:
• a pulse generator circuit including:
• a pulse output circuit to deliver cardiac pacing pulses;
• a sensor circuit to sense one or more signals indicative of a need for and an effect of the delivery of the electrical pulses and the delivery of the drug;
• and
• an implant controller including a sensor processing circuit adapted to process the one or more signals and a therapy controller adapted to control the delivery of the cardiac pacing pulses and the delivery of the drug using the processed one or more signals;
• and
• a first implantable housing configured to encapsulate the pulse generator circuit;
• and
• an implantable drug delivery device to deliver a drug, the implantable drug delivery device including:
• a drug reservoir to contain the drug;
• a second implantable housing configured to encapsulate portions of a structure of the implantable drug delivery device including the drug reservoir, the second implantable housing fastened to the first implantable housing;
• and
• a reservoir filling port constructed on the second implantable housing, the reservoir filling port including a self-resealable portion adapted to allow filling of the drug reservoir through a hollow needle,
• wherein the therapy controller is adapted to control the delivery of the cardiac pacing pulses by alternately executing a cardiac resynchronization therapy (CRT) algorithm adapted to maximize a measure of hemodynamic performance and a remodeling control (RCT) algorithm adapted to alter a cardiac remodeling process.