System, apparatus and method for diagnosing seizures
AssigneeCase Western Reserve University
InventorsTanvir U. Syed, Farhad Kaffashi, Ken Loparo, Hans O. Luders
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Abstract
Systems and methods can be used to help discriminate between epileptic and non-epileptic seizures based on a relationship between the postictal heart electrical activity and the preictal heart electrical activity. Also disclosed is an approach to determine an R-R interval by using a time-invariant complex wavelet transform.
Claims37
A non-transitory machine readable medium having instructions to perform a method comprising:
- detecting a preictal heart rate associated with a given event for a patient, the preictal heart rate being a heart rate detected during a time period prior to a beginning of the given event;
- detecting a postictal heart rate associated with the given event, the postictal heart rate being a heart rate detected during a time period after the given event;
- calculating at least one heart rate index based on a comparative analysis of the postictal heart rate relative to the preictal heart rate;
- determining whether the given event is an epileptic seizure event or a non-epileptic event based on the heart rate index;
- and
- providing an output identifying the given event as being epileptic or non-epileptic based on the determination of the given event.
An apparatus to discriminate between epileptic and non-epileptic events, comprising:
- non-transitory memory to store heart electrical measurement data for at least before and after a given event;
- a processor to access and execute instructions stored in the memory, the instructions comprising:
- an interval selector method programmed to designate the heart electrical measurement data as preictal heart electrical data or postictal heart electrical data, the preictal heart electrical data being detected during a time period prior to a beginning of the given event, and the postictal heart electrical data being detected during a time period after the given event;
- an index calculator method programmed to determine an index based on a comparative analysis of the preictal heart electrical data relative to the postictal heart electrical data, the index quantifying a relationship between postictal heart electrical activity and preictal heart electrical activity;
- a classifier method programmed to indicate whether the given event is an epileptic seizure event or a non-epileptic event based on the index.
A method to discriminate between epileptic and non-epileptic events comprising:
- identifying a given event for a patient;
- detecting a preictal heart rate associated with the given event for the patient, the preictal heart rate being a heart rate detected during a time prior to a beginning of the given event;
- detecting a postictal heart rate associated with the given event, the postictal heart rate being a heart rate detected during a time after the given event;
- determining the given event as being one of an epileptic seizure event or a non-epileptic event based on a comparative analysis of the postictal heart rate relative to the preictal heart rate;
- and
- providing an output specifying the given event as being epileptic or non-epileptic based on the determination of the given event.
Dependencies are inferred from the claim text.