Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution

A method for generating data associated with at least one portion of an anatomical sample, comprising:

• forwarding at least one first radiation at to the at least one portion through at least one optical arrangement, and receiving at least one second radiation from the at least one portion which is based on the at least one first radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the first radiation or the second radiation, the at least one optical arrangement has a first transfer function;
• forwarding at least one third radiation to the at least one portion through the at least one optical arrangement, and receiving at least one fourth radiation from the at least one portion which is based on the at least one third radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the third radiation or the fourth radiation, the at least one optical arrangement has a second transfer function, and wherein the first transfer function is at least partially different from the second transfer function;
• and
• generating the data based on the second and fourth radiations, wherein, when the first and third radiations impact the at least one optical arrangement having an optical aperture, the resultant respective radiations are at least partially focused to at least one of (i) a depth of focus or (ii) a focal range that is greater than approximately a Raleigh range of a full aperture of illumination.

A method for generating data associated with at least one portion of an anatomical sample, comprising:

• forwarding at least one first radiation at to the at least one portion through at least one optical arrangement, and receiving at least one second radiation from the at least one portion which is based on the at least one first radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the first radiation or the second radiation, the at least one optical arrangement has a first transfer function;
• forwarding at least one third radiation to the at least one portion through the at least one optical arrangement, and receiving at least one fourth radiation from the at least one portion which is based on the at least one third radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the third radiation or the fourth radiation, the at least one optical arrangement has a second transfer function, and wherein the first transfer function is at least partially different from the second transfer function;
• generating the data based on the second and fourth radiations;
• and
• receiving at least one fifth radiation from a reference arrangement, combining at least one of the second radiation or the fourth radiation with at least one fifth radiation to generate a further radiation, and generating the data as a further function of the further radiation.

A method for generating data associated with at least one portion of an anatomical sample, comprising:

• forwarding at least one first radiation at to the at least one portion through at least one optical arrangement, and receiving at least one second radiation from the at least one portion which is based on the at least one first radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the first radiation or the second radiation, the at least one optical arrangement has a first transfer function;
• forwarding at least one third radiation to the at least one portion through the at least one optical arrangement, and receiving at least one fourth radiation from the at least one portion which is based on the at least one third radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the third radiation or the fourth radiation, the at least one optical arrangement has a second transfer function, and wherein the first transfer function is at least partially different from the second transfer function;
• and
• generating the data based on the second and fourth radiations, wherein the at least one optical arrangement is configured to be illuminated by a ring-shaped beam which has a plurality of rings which include at least one of diameters or thicknesses that are different from one another.

A method for generating data associated with at least one portion of an anatomical sample, comprising:

• forwarding at least one first radiation at to the at least one portion through at least one optical arrangement, and receiving at least one second radiation from the at least one portion which is based on the at least one first radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the first radiation or the second radiation, the at least one optical arrangement has a first transfer function;
• forwarding at least one third radiation to the at least one portion through the at least one optical arrangement, and receiving at least one fourth radiation from the at least one portion which is based on the at least one third radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the third radiation or the fourth radiation, the at least one optical arrangement has a second transfer function, and wherein the first transfer function is at least partially different from the second transfer function;
• and
• generating the data based on the second and fourth radiations, wherein the at least one optical arrangement includes at least one axicon lens arrangement.

A method for generating data associated with at least one portion of an anatomical sample, comprising:

• forwarding at least one first radiation at to the at least one portion through at least one optical arrangement, and receiving at least one second radiation from the at least one portion which is based on the at least one first radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the first radiation or the second radiation, the at least one optical arrangement has a first transfer function;
• forwarding at least one third radiation to the at least one portion through the at least one optical arrangement, and receiving at least one fourth radiation from the at least one portion which is based on the at least one third radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the third radiation or the fourth radiation, the at least one optical arrangement has a second transfer function, and wherein the first transfer function is at least partially different from the second transfer function;
• and
• generating the data based on the second and fourth radiations, wherein the data is generated by utilizing information associated with at least one of the first transfer function or the second transfer function.

A method for generating data associated with at least one portion of an anatomical sample, comprising:

• forwarding at least one first radiation at to the at least one portion through at least one optical arrangement, and receiving at least one second radiation from the at least one portion which is based on the at least one first radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the first radiation or the second radiation, the at least one optical arrangement has a first transfer function;
• forwarding at least one third radiation to the at least one portion through the at least one optical arrangement, and receiving at least one fourth radiation from the at least one portion which is based on the at least one third radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the third radiation or the fourth radiation, the at least one optical arrangement has a second transfer function, and wherein the first transfer function is at least partially different from the second transfer function;
• and
• generating the data based on the second and fourth radiations, wherein the data is generated by at least one filtering or scaling information associated with at least one of the first transfer function or the second transfer function.

An apparatus for generating data associated with at least one portion of an anatomical sample, comprising:

• at least one optical arrangement configured to:
• i. forward at least one first radiation at to the at least one portion through at least one optical arrangement, and receiving at least one second radiation from the at least one portion within the anatomical sample which is based on the at least one first radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the first radiation or the second radiation, the at least one optical arrangement has a first transfer function,
• ii. forward at least one third radiation to the at least one portion through the at least one optical arrangement, and receiving at least one fourth radiation from the at least one portion within the anatomical sample which is based on the at least one third radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the third radiation or the fourth radiation, the at least one optical arrangement has a second transfer function, and wherein the first transfer function is at least partially different from the second transfer function;
• and
• at least one further arrangement configured to generate the data based on the second and fourth radiations.

An apparatus for generating data associated with at least one portion of a sample, comprising:

• at least one optical arrangement configured to:
• i. forward at least one first radiation at to the at least one portion through at least one optical arrangement, and receiving at least one second radiation from the at least one portion which is based on the at least one first radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the first radiation or the second radiation, the at least one optical arrangement has a first transfer function,
• ii. forward at least one third radiation to the at least one portion through the at least one optical arrangement, and receiving at least one fourth radiation from the at least one portion which is based on the at least one third radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the third radiation or the fourth radiation, the at least one optical arrangement has a second transfer function, and wherein the first transfer function is at least partially different from the second transfer function;
• at least one further arrangement configured to generate the data based on the second and fourth radiations;
• and
• a switching arrangement which is configured to switch an illumination of (i) the first radiation or the third radiation, or (ii) the second radiation or the fourth radiation.

An apparatus for generating data associated with at least one portion of a sample, comprising:

• at least one optical arrangement configured to:
• i. forward at least one first radiation at to the at least one portion through at least one optical arrangement, and receiving at least one second radiation from the at least one portion which is based on the at least one first radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the first radiation or the second radiation, the at least one optical arrangement has a first transfer function,
• ii. forward at least one third radiation to the at least one portion through the at least one optical arrangement, and receiving at least one fourth radiation from the at least one portion which is based on the at least one third radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the third radiation or the fourth radiation, the at least one optical arrangement has a second transfer function, and wherein the first transfer function is at least partially different from the second transfer function;
• at least one further arrangement configured to generate the data based on the second and fourth radiations;
• and
• a multiplexing arrangement which is configured to arrange an illumination of (i) the first radiation and the third radiation, or (ii) the second radiation and the fourth radiation with respect to time, wavelength or coherence length.

An apparatus for generating data associated with at least one portion of a sample, comprising:

• at least one optical arrangement configured to:
• i. forward at least one first radiation at to the at least one portion through at least one optical arrangement, and receiving at least one second radiation from the at least one portion which is based on the at least one first radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the first radiation or the second radiation, the at least one optical arrangement has a first transfer function,
• ii. forward at least one third radiation to the at least one portion through the at least one optical arrangement, and receiving at least one fourth radiation from the at least one portion which is based on the at least one third radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the third radiation or the fourth radiation, the at least one optical arrangement has a second transfer function, and wherein the first transfer function is at least partially different from the second transfer function;
• at least one further arrangement configured to generate the data based on the second and fourth radiations;
• and
• at least one further processing arrangement which is configured to generate the data by utilizing at least one of the first transfer function or the second transfer function.

An apparatus for generating data associated with at least one portion of an anatomical sample, comprising:

• at least one first optical arrangement configured to forward at least one first radiation at to the at least one portion through at least one optical arrangement, and receiving at least one second radiation from the at least one portion within the anatomical sample which is based on the at least one first radiation, wherein, based on an interaction between the at least one first optical arrangement and at least one of the first radiation or the second radiation, the at least one first optical arrangement has a first transfer function,
• at least one second optical arrangement configured to forward at least one third radiation to the at least one portion through the at least one second optical arrangement, and receiving at least one fourth radiation from the at least one portion within the anatomical sample which is based on the at least one third radiation, wherein, based on an interaction between the at least one second optical arrangement and at least one of the third radiation or the fourth radiation, the at least one second optical arrangement has a second transfer function, and wherein the first transfer function is at least partially different from the second transfer function;
• and
• at least one third arrangement configured to generate the data based on the second and fourth radiations.

A method for generating data associated with at least one portion of an anatomical sample, comprising:

• forwarding at least one first radiation at to the at least one portion through at least one first optical arrangement, and receiving at least one second radiation from the at least one portion within the anatomical sample which is based on the at least one first radiation, wherein, based on an interaction between the at least one first optical arrangement and at least one of the first radiation or the second radiation, the at least one first optical arrangement has a first transfer function;
• forwarding at least one third radiation to the at least one portion through at least one second optical arrangement, and receiving at least one fourth radiation from the at least one portion within the anatomical sample which is based on the at least one third radiation, wherein, based on an interaction between the at least one second optical arrangement and at least one of the third radiation or the fourth radiation, the at least one second optical arrangement has a second transfer function, and wherein the first transfer function is at least partially different from the second transfer function;
• and
• generating the data based on the second and fourth radiations.

A method for generating data associated with at least one portion of a sample, comprising:

• forwarding at least one first radiation at to the at least one portion through at least one optical arrangement, and receiving at least one second radiation from the at least one portion which is based on the at least one first radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the first radiation or the second radiation, the at least one optical arrangement has a first transfer function;
• forwarding at least one third radiation to the at least one portion through the at least one optical arrangement, and receiving at least one fourth radiation from the at least one portion which is based on the at least one third radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the third radiation or the fourth radiation, the at least one optical arrangement has a second transfer function, and wherein the first transfer function is at least partially different from the second transfer function;
• separating the at least one second radiation and the at least one fourth radiation from one another;
• and
• generating the data based on the separated second and fourth radiations.

An apparatus for generating data associated with at least one portion of a sample, comprising:

• at least one optical arrangement configured to:
• i. forward at least one first radiation at to the at least one portion through at least one optical arrangement, and receiving at least one second radiation from the at least one portion which is based on the at least one first radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the first radiation or the second radiation, the at least one optical arrangement has a first transfer function,
• ii. forward at least one third radiation to the at least one portion through the at least one optical arrangement, and receiving at least one fourth radiation from the at least one portion which is based on the at least one third radiation, wherein, based on an interaction between the at least one optical arrangement and at least one of the third radiation or the fourth radiation, the at least one optical arrangement has a second transfer function, and wherein the first transfer function is at least partially different from the second transfer function;
• and
• at least one further arrangement configured to (i) separate the at least one second radiation and the at least one fourth radiation from one another, and (ii) generate the data based on the separated second and fourth radiations.