Mass spectrometer arranged to perform MS/MS/MS
AssigneeMicromass UK Limited
InventorDaniel James Kenny
Life of this patent
Estimating the term…
Abstract
A mass spectrometer is disclosed comprising an ion trap and a fragmentation device. Ions are fragmented in the ion trap to form first generation fragment ions. The ion trap has a relatively high mass cut-off. The first generation fragment ions are then transferred to a fragmentation device which is arranged to have a substantially lower low mass cut-off. The first generation fragment ions are fragmented within the fragmentation device any may optionally be stored in an ion accumulation region prior to being passed to a mass analyzer for subsequent mass analysis.
Claims16
A method of mass spectrometry comprising:
- accumulating ions within an ion trap;
- isolating ions of interest within said ion trap;
- fragmenting at least some of said ions of interest within said ion trap to form a plurality of first fragment ions;
- transferring at least some of said first fragment ions to a fragmentation device which is arranged either upstream or downstream of said ion trap;
- and
- fragmenting at least some said first fragment ions within said fragmentation device to form a plurality of second fragment ions.
A mass spectrometer comprising:
- an ion trap and a fragmentation device arranged upstream or downstream of said ion trap;
- wherein in a mode of operation ions are accumulated within said ion trap, ions of interest are isolated within said ion trap and at least some of said ions of interest are fragmented within said ion trap to form a plurality of first fragment ions, wherein at least some of said first fragment ions are then transferred to said fragmentation device and wherein at least some of said first fragment ions are fragmented within said fragmentation device to form a plurality of second fragment ions.
A method of mass spectrometry comprising:
- isolating ions of interest within an ion trap;
- fragmenting at least some of said ions of interest within said ion trap to form a plurality of first fragment ions;
- isolating first fragment ions of interest within said ion trap;
- fragmenting at least some of said first fragment ions of interest within said ion trap to form a plurality of second fragment ions;
- transferring at least some of said second fragment ions to a fragmentation device which is arranged either upstream or downstream of said ion trap;
- and
- fragmenting at least some said second fragment ions within said fragmentation device to form a plurality of third fragment ions.
A mass spectrometer comprising:
- an ion trap and a fragmentation device arranged upstream or downstream of said ion trap;
- wherein in a mode of operation ions of interest are isolated within said ion trap and at least some of said ions of interest are fragmented within said ion trap to form a plurality of first fragment ions, wherein at least some of said first fragment ions are then isolated within said ion trap and are then fragmented within said ion trap to form a plurality of second fragment ions, wherein at least some of said second fragment ions are transferred to said fragmentation device and wherein at least some of said second fragment ions are fragmented within said fragmentation device to form a plurality of third fragment ions.
Dependencies are inferred from the claim text.