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US 8,802,920 B2Granted
Acellular tissue matrices made from α-1,3-galactose-deficient tissue
AssigneeLifeCell Corporation
InventorsDavid J. McQuillan, Edward S. Griffey, Herbert Daniel Beniker, Hui Xu
Life of this patent
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Abstract
The invention provides acellular tissue matrices made from collagen-containing tissues of animals genetically modified so as to be deficient in the galactose 1,3-galactose epitope and methods of making and using such acellular tissue matrices.
Claims20
An acellular tissue matrix comprising:
- a decellularized collagen-containing dermal tissue of a pig genetically modified to include a chromosomal genetic modification comprising a disruption of both alleles of an α-1,3 galactosyl transferase (αGT) gene such that tissues in the pig lack galactose α-1,3-galactose epitopes,
- wherein the acellular tissue matrix lacks epithelial basement membrane.
A method of making an acellular tissue matrix, the method comprising:
- (a) providing a collagen-containing tissue from a pig genetically modified to include a chromosomal genetic modification comprising a disruption of both alleles of an α-1,3 galactosyl transferase (αGT) gene so that tissues in the pig lack galactose α-1,3-galactose epitopes;
- and
- (b) processing the tissue so as to render the tissue acellular and lacking an epithelial basement membrane, the processing resulting in the production of an acellular tissue matrix.
Dependencies are inferred from the claim text.