Amide derivatives of benzene-sulfonanilide, pharmaceutical composition thereof and method for cancer treatment using the same
AssigneeCleveland State University
InventorsBin Su, Aimin Zhou, Yan Xu
Life of this patent
Estimating the term…
Abstract
The invention provides a compound of formula (I), a pharmaceutical composition thereof, a method of preparing a medicament for the treatment of a cancer, and a method of treating cancers. The invention exhibits merits against cancers such as significantly higher potency and effectiveness over a broader range of cancers. In formula (I), Ra is a benzyl group with alkyl and/or alkoxy; Rb is selected from H and alkyl groups; Rf is an alkyl; and R3 is selected from a substituted phenyl, a heterocyclic group, and wherein Rc is selected from a fused ring, fused rings, and any bivalent cyclic group.
Claims27
A compound of formula (I):
- wherein Ra is
- R1 and R2 are independently of each other selected from alkoxy groups;
- Rb is selected from H and alkyl groups;
- Rf is an alkyl;
- and R3 is selected from:
- wherein R4 is selected from halo, phenyl, substituted phenyl, and alkoxy;
- wherein R5 and R6 are independently of each other selected from alkoxy groups;
- and
- wherein Rc is selected from a fused ring, fused rings, and any bivalent carbon- or hetero-cyclic group.
A compound of formula (I):
- wherein Ra is
- R1 and R2 are independently of each other selected from alkyl groups;
- Rb is selected from H and alkyl groups;
- Rf is an alkyl;
- and R3 is selected from heterocyclic group, a phenyl group which is mono-, di-, or tri-substituted with alkoxy, alkylthio, and halo-substituted alkoxy, and
- wherein Rc is selected from any bivalent carbon or heterocyclic group.
A compound of formula (I):
- wherein Ra is
- R1 and R2 are independently of each other selected from alkyl groups;
- Rb is selected from H and alkyl groups;
- Rf is an alkyl;
- and R3 is heterocyclic group.
A compound of formula (I):
- wherein Ra is
- R1 and R2 are independently of each other selected from alkyl and alkoxy groups;
- Rb is selected from H and alkyl groups;
- Rf is an alkyl;
- and R3 is selected from heterocyclic group, a phenyl group which is mono-, di-, or tri-substituted with alkoxy, alkylthio, and halo-substituted alkoxy, and
- wherein Rc is selected from any bivalent carbon or heterocyclic group.
Dependencies are inferred from the claim text.