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US 8,802,892 B2Granted
Functionalized phenolic compounds and polymers therefrom
AssigneeBezwada Biomedical, LLC
InventorRao S Bezwada
Life of this patent
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Abstract
The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X)p—R′]q I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
Claims13
A compound of formula (I) or a pharmaceutically acceptable salt thereof:
- Ar—[O—(X)p—R′]q (I)
- wherein:
- Ar is the remainder of a phenolic residue and is selected from:
- resorcinol, catechol, dihydroxy-naphthyl, tri-hydroxy-naphthyl, tetra-hydroxy-naphthyl, unsubstituted hydroquinone, tri-hydroxy-phenyl, di-hydroxy-benzoic acids, and isoflavones;
- X is independently at each occurrence selected
- from:
- —CH2COO—;
- —CH(CH3)COO—;
- —CH2CH2OCH2COO—;
- —CH2CH2CH2CH2CH2COO—;
- —(CH2)yCOO—;
- and, —(CH2CH2O)zCH2COO—;
- y is independently selected from 2, 3, 4 and 6-24;
- z is independently selected from 2-24;
- R′ is selected from H, benzyl, and C1-6 alkyl;
- p is independently selected from 2, 3, and 4;
- and,
- q is selected from 2, 3, 4, 5, 6, 7, 8, 9, and 10.
15 more elements
Dependencies are inferred from the claim text.