Benzo lipoxin analogues
AssigneeUniversity of Southern California
InventorNicos A. Petasis
Life of this patent
Estimating the term…
Abstract
Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease and abnormal cell proliferation.
Claims79
A compound having a structural and stereochemical formula selected from the group consisting of:
- wherein:
- A is hydroxy, alkoxy, aryloxy, amino, alkylamino, dialkylamino or OM, wherein M is an ammonium, tetra-alkyl ammonium, sodium, potassium, magnesium or zinc cation;
- W is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, halo, hydroxy, alkoxy, aryloxy, carboxy, amino, alkylamino, dialkylamino, acylamino, carboxamido, or sulfonamide;
- Ra-Rc are each independently hydrogen, alkyl, aryl, acyl or alkoxyacyl;
- n is zero, one or two;
- and
- m is one or two,
- or a pharmaceutically acceptable salt thereof.
A compound having a structural and stereochemical formula selected from the group consisting of:
- wherein:
- A is hydroxy, alkoxy, aryloxy, amino, alkylamino, dialkylamino or OM, wherein M is an ammonium, tetra-alkyl ammonium, sodium, potassium, magnesium or zinc cation;
- W is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, halo, hydroxy, alkoxy, aryloxy, carboxy, amino, alkylamino, dialkylamino, acylamino, carboxamido, or sulfonamide;
- or a pharmaceutically acceptable salt thereof.
A compound having a structural and stereochemical formula selected from the group consisting of:
- wherein:
- A is hydroxy, alkoxy, aryloxy, amino, alkylamino, dialkylamino or OM, wherein M is an ammonium, tetra-alkyl ammonium, sodium, potassium, magnesium or zinc cation;
- W is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, halo, hydroxy, alkoxy, aryloxy, carboxy, amino, alkylamino, dialkylamino, acylamino, carboxamido, or sulfonamide;
- Ra-Rc are each independently hydrogen, alkyl, aryl, acyl or alkoxyacyl;
- m is one or two,
- or a pharmaceutically acceptable salt thereof.
A compound having a structural and stereochemical formula selected from the group consisting of:
- wherein:
- A is hydroxy, alkoxy, aryloxy, amino, alkylamino, dialkylamino or OM, wherein M is an ammonium, tetra-alkyl ammonium, sodium, potassium, magnesium or zinc cation;
- W is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, halo, hydroxy, alkoxy, aryloxy, carboxy, amino, alkylamino, dialkylamino, acylamino, carboxamido, or sulfonamide;
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a compound having a structural and stereochemical formula selected from the group consisting of:
- wherein:
- A is hydroxy, alkoxy, aryloxy, amino, alkylamino, dialkylamino or OM, wherein M is an ammonium, tetra-alkyl ammonium, sodium, potassium, magnesium or zinc cation;
- or a pharmaceutically acceptable salt thereof;
- and a pharmaceutically acceptable carrier.
A substantially diastereomerically pure, optical isomer of a compound selected from the group consisting of:
- wherein:
- A is hydroxy, alkoxy, aryloxy, amino, alkylamino, dialkylamino or OM, wherein M is an ammonium, tetra-alkyl ammonium, sodium, potassium, magnesium or zinc cation;
- W is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, halo, hydroxy, alkoxy, aryloxy, carboxy, amino, alkylamino, dialkylamino, acylamino, carboxamido, or sulfonamide;
- Ra-Rc are each independently hydrogen, alkyl, aryl, acyl or alkoxyacyl;
- n is zero, one or two;
- and
- m is one or two,
- or a pharmaceutically acceptable salt thereof.
A substantially diastereomerically pure, optical isomer of a compound with the formula:
A substantially diastereomerically pure, optical isomer of a compound with the formula:
- wherein:
- A is hydroxy, alkoxy, aryloxy, amino, alkylamino, dialkylamino or OM, wherein M is an ammonium, tetra-alkyl ammonium, sodium, potassium, magnesium or zinc cation;
- W is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, halo, hydroxy, alkoxy, aryloxy, carboxy, amino, alkylamino, dialkylamino, acylamino, carboxamido, or sulfonamide;
- Ra-Rc are each independently hydrogen, alkyl, aryl, acyl or alkoxyacyl;
- and
- m is one or two,
- or a pharmaceutically acceptable salt thereof.
A substantially diastereomerically pure, optical isomer of a compound with the formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.