Pyridinylimidazolone derivatives for the inhibition of PI3 kinases

A compound of the formula I

• in which
• X1 denotes CR1 or N,
• X2 denotes CR1 or N,
• where X1 or X2 denotes N
• and the other X1 or X2 denotes CR1,
• Y denotes Het or Ar,
• L denotes [C(Ra)2]m,
• R1 denotes H, A, Hal, OH, OA, NH2, NHA or NA2,
• R2 denotes H, A, Hal, OH, OA, NH2, NHA or NA2,
• R3 denotes H, A, Hal, OH, OA, NH2, NHA or NA2,
• R4 denotes H, A′, OH or OA′,
• R5 denotes H or A′,
• R6 denotes H, A″, CN, Hal, Het, Het1 or Ar,
• R7 denotes H or A′″,
• R8 denotes H, A″, Het1, CN, Hal, NHHet1, NA′Het1, Ar or Het,
• R9 denotes H, A″, CN, Hal, Het, Het1 or Ar,
• R10 denotes H, A″, CN, Hal, Het, Het1 or Ar,
• A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms are optionally replaced by F and/or Cl, or cyclic alkyl having 3-7 C atoms,
• A′ denotes unbranched or branched alkyl having 1-6 C atoms, in which 1-5 H atoms are optionally replaced by F and/or Cl,
• A″ denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms are optionally replaced by OH, CN, NH2, CONH2, COOH, COOA, NHCOA, —C≡H, F, Cl and/or Br, and/or in which one or two non-adjacent CH and/or CH2 groups are optionally replaced by O, NH, NA′, S, SO, SO2 and/or CH═CH groups,
• A′″ denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms are optionally replaced by F and/or Cl, and/or in which one or two non-adjacent CH and/or CH2 groups are optionally replaced by O, NH and/or NA′,
• Ra denotes H or A′,
• Het denotes a mono- or bicyclic unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono-, di- or trisubstituted by A, (CH2)nNH2, (CH2)nNHA, (CH2)nNA2, NHCOA, (CH2)nCONH2, (CH2)nCONHA, (CH2)nCONA2, CN, ═O, Hal, (CH2)nOH, (CH2)nOA, COOH, COOA, O(CH2)nOH, O(CH2)nOA, O(CH2)nNH2, NH(CH2)nNH2, SO2A and/or SO2NH2,
• Ar denotes phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di- or trisubstituted by CN, (CH2)nCONH2, (CH2)nCONHA, (CH2)nCONA2, (CH2)nOH, (CH2)nOA, (CH2)nNH2, (CH2)nNHA, (CH2)nNA2, NHCOOA, NHCOA, Hal, COOH, COOA, A, NHSO2A, SO2NH2, SO2NHA, SO2NA2 and/or SO2A,
• Het1 denotes a monocyclic saturated heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono-, disubstituted by A, NH2, pyridylmethyl and/or ═O,
• Hal denotes F, Cl, Br or I,
• m denotes 0 or 1,
• n denotes 0, 1, 2, 3 or 4,
• or a pharmaceutically usable salt, tautomer or stereoisomer thereof, including mixtures thereof in all ratios.