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US 8,802,864 B2Granted
Triazolones as fatty acid synthase inhibitors
AssigneeGlaxoSmithKline LLC
InventorsNicholas D. Adams, Christopher Joseph Aquino, Amita M. Chaudhari, Jonathan M. Ghergurovich, Terence John Kiesow, Cynthia A. Parrish, Alexander Joseph Reif, Kenneth Wiggall
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Abstract
This invention relates to the use of triazolone derivatives of Formula (I) for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of triazolones in the treatment of cancer.
Claims15
A compound of Formula (I),
- wherein,
- R1 is a 6-membered aryl or heteroaryl ring which may be substituted or unsubstituted, in which adjacent substituents together may form an additional optionally substituted five or six membered ring which contains 0-3 heteroatoms and 0 to 2 double bonds;
- each R3 is independently selected from the group consisting of:
- halogen, C1-6alkyl, hydroxyl, and alkoxy;
- R4 is H or C1-6alkyl;
- R5 is selected from the group consisting of:
- C1-6alkyl, C3-7cycloalkyl, —OC1-6alkyl, C4-6heterocycloalkyl, amino and alkylamino;
- m is 0-3, n is 0-1;
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.