Amino alcohol cationic lipids for oligonucleotide delivery

A lipid of Formula A:

• wherein:
• R1 and R2 are independently selected from H, (C1-C6)alkyl, heterocyclyl and polyamine, wherein said alkyl, heterocyclyl and polyamine are optionally substituted with one to three substituents selected from R′, or R1 and R2 can be taken together with the nitrogen to which they are attached to form a monocyclic heterocycle with 4-7 members optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocyclic heterocycle is optionally substituted with one to three substituents selected from R′;
• R3 is selected from H and (C1-C6)alkyl, wherein said alkyl is optionally substituted with one to three substituents selected from R′, or R3 can be taken together with R1 to form a monocyclic heterocycle with 4-7 members optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocyclic heterocycle is optionally substituted with one to three substituents selected from R′;
• R′ is independently selected from halogen, R″, OR″, SR″, CN, CO2R″ and CON(R″)2;
• R″ is independently selected from H and (C1-C6)alkyl, wherein said alkyl is optionally substituted with halogen and OH;
• L1 is C4-C22 alkenyl, said alkenyl is optionally substituted with R′;
• and
• L2 is selected from C4-C22 alkyl and C4-C22 alkenyl, said alkyl and alkenyl are optionally substituted with R′;
• or any pharmaceutically acceptable salt or stereoisomer thereof.