1,2-benzisothiazol-3-one compound production method
AssigneeSumitomo Seika Chemicals Co., Ltd.
InventorsTakehiro Hiyama, Ichiro Yokoe, Takeshi Takeuchi, Michio Suzuki
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Abstract
The present invention provides a method for producing 1,2-benzisothiazol-3-one compounds by reacting a 2-(alkylthio)benzonitrile compound with a halogenating agent in the presence of water, the method being characterized in that the reaction proceeds while the halogenating agent and water are gradually and simultaneously added to a reaction system containing the 2-(alkylthio)benzonitrile compound. The invention allows the simple and economical production of highly pure 1,2-benzisothiazol-3-one compounds, which are useful as antimicrobial agents, antifungal agents, etc.
Claims4
A method for producing a 1,2-benzisothiazol-3-one compound represented by formula (2):
- wherein R1 is a hydrogen atom, C1-4 alkyl group, C1-4 alkoxy group, nitro group, carboxyl group, alkoxycarbonyl group, or halogen atom,
- the method comprising reacting a 2-(alkylthio)benzonitrile compound represented by formula (1):
- wherein R1 is as defined above and R2 is a C1-4 alkyl group, with a halogenating agent in the presence of water,
- wherein the halogenating agent and water are gradually and simultaneously added to a reaction system containing the 2-(alkylthio)benzonitrile compound to proceed the reaction.
Dependencies are inferred from the claim text.