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US 8,802,853 B2Granted
Arylalkenyl and arylalkynyl substituted imidazoquinolines
Assignee3M Innovative Properties Company
InventorsJason D. Bonk, Joseph F. Dellaria, Jr.
Life of this patent
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Abstract
Arylalkenyl and aryalkynyl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
Claims15
A compound of the formula (II):
- wherein:
- Z is —C≡C—;
- X′ is —CH(R3)—;
- R1 is selected from the group consisting of:
- —Ar and
- —Ar′—Y—R4;
- Ar is phenyl which can be unsubstituted or can be substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, hydroxyalkyl, mercapto, cyano, carboxy, formyl, amino, alkylamino, and dialkylamino;
- Ar′ is phenylene;
- R2 is selected from the group consisting of hydrogen and alkyl, wherein the alkyl group can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl and alkoxy;
- Y is selected from the group consisting of:
- —C(R6)—,
- —C(R6)—O—,
- —O—C(R6)—, and
- —O—C(O)—O—;
- R3 is hydrogen or C1-10 alkyl;
- R4 is selected from the group consisting of hydrogen, alkyl, and alkenyl;
- R6 is ═O;
- and
- n is 0;
- or a pharmaceutically acceptable salt thereof.
17 more elements
Dependencies are inferred from the claim text.