Process for preparing substituted 5-fluoro-1H-pyrazolopyridines
AssigneeBayer Intellectual Property GmbH
InventorPeter Fey
Life of this patent
Estimating the term…
Abstract
The present application relates to a novel and efficient process for preparing novel substituted 5-fluoro-1H-pyrazolopyridines of the formula (VI) which are suitable as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders. More particularly, the 5-fluoro-1H-pyrazolopyridines of the formula (VI) are suitable for preparation of the compound of the formula (I) which serves for production of medicaments, for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders.
Claims2
A process of preparing a compound of formula (I), comprising using the compound of formula (VI)
- to prepare a compound of formula (I)
- wherein the compound of formula (I) is optionally converted with an appropriate (i) solvent and/or (ii) acid or base to the solvate, salt and/or solvate of the salt thereof.
A process of preparing a compound of formula (I)
- by converting the compound of the formula (VI) to the compound of the formula (VII)
- reacting the compound of formula (VII) in an inert solvent in the presence of a suitable base with the compound of the formula (VIIIa)
- to give the compound of the formula (VIII)
- and reducing the compound of formula (VIII) in an inert solvent in the presence of a suitable reducing agent to give the compound (IX)
- and reacting the compound of formula (IX) with methyl chloroformate or with dimethyl dicarbonate in the presence of a suitable base with or without solvent to give the compound of the formula (I), and
- optionally, converting the resulting compound of formula (I) with the appropriate (i) solvent and/or (ii) acid or base to the solvate, salt and/or solvate of the salt thereof.
Dependencies are inferred from the claim text.