Nucleic acids molecule encoding the polypeptide for treating virus-induced cancer
AssigneePheromonicin Biotech, Ltd.
InventorXiao-Qing Qiu
Life of this patent
Estimating the term…
Abstract
The present invention relates to nucleic acid molecules encoding the polypeptides that are capable of killing tumor cells. The molecules comprise a targeting agent covalently attached to a channel-forming moiety. In a preferred embodiment, the channel-forming moiety comprises a colicin and the targeting agent is a reconstructed antibody mimetic derived from monoclone antibody against Epstein-Barr virus gp350/220.
Claims24
A nucleic acid molecule encoding a fusion polypeptide for treating a cell proliferative disorder in a mammal, the fusion polypeptide comprising:
- a cancer cell targeting agent that targets mammalian cancer cells covalently attached to a channel-forming moiety, wherein said channel-forming moiety is a colicin selected from the group consisting of E1, Ia, Ib, A, K or N.
A nucleic acid molecule encoding a fusion polypeptide for the treatment of a cell proliferative disorder in a mammalian, the fusion polypeptide comprising:
- a cancer cell targeting moiety being a reconstructed antibody mimetic derived from engineered antibody against Epstein-Barr virus gp350/220 envelope glycoprotein complex that targets mammalian cancer cells;
- and
- a channel-forming domain of colicin covalently linked to the cancer cell targeting moiety.
A nucleic acid molecule encoding a fusion polypeptide, the fusion polypeptide comprising the amino acid sequence of SEQ ID NO:
- 11.
Dependencies are inferred from the claim text.