Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier

A compound of Formula I:

• wherein
• R is hydrogen, alkyl, —C(O)-alkyl, or the group -L-S where L is a covalent bond or is a biocompatible, cleavable linking group and S is a dehydrating saccharide or oligosaccharide;
• R1 is hydrogen or the group -L-S where L is a covalent bond or is a biocompatible, cleavable linking group and S is a dehydrating saccharide or oligosaccharide;
• provided that at least one of R and R1 is -L-S;
• or a pharmaceutically acceptable salt thereof.