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US 8,802,821 B2Granted
Polypeptides having DNA demethylase activity
AssigneeThe Regents of the University of California
InventorsRobert Fischer, Jon Penterman, Jin Hoe Huh, Tzung-Fu Hsieh
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Abstract
Polypeptides with DNA demethylase activity as well as methods of their use are provided.
Claims2
An isolated polypeptide comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:3, wherein the amino acid corresponding to position 627 in SEQ ID NO:3 is an aspartic acid, wherein the isolated polypeptide excises methylated cytosines in DNA when contacted with DNA comprising methylated cytosines, and wherein the isolated polypeptide does not comprise the amino acid sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.