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US 8,802,815 B2Granted
Peptides and uses thereof to modulate IGF-1 synthesis and IGF-1 receptor expression
AssigneeUniversite Pierre Et Marie Curie (Paris 6)
InventorsClaude Carelli, Zvi Laron, Gila Maor
Life of this patent
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Abstract
The invention relates to peptides for modulate IGF-1 activity, a pharmaceutical composition comprising them as well as their applications as medicinal products and cell proliferation modulating agents in vitro.
Claims10
An isolated peptide comprising the 20 to 24 amino acids following sequence (I):
- Pa-X1-Phe-Trp-X2-X3-Pb(I)
- (SEQ ID NO:
- 1)
- in which:
- Pa represents a sequence comprising 10 to 12 amino acids selected from the sequences:
- (SEQ ID NO:
- 3)
- Phe-Gly-Ser-Arg-Lys-Phe-Ser-Tyr-Lys-Ala
- (SEQ ID NO:
- 4)
- Asn-Phe-Gly-Ser-Arg-Lys-Phe-Ser-Tyr-Lys-Ala
- (SEQ ID NO:
- 5)
- Ser-Asn-Phe-Gly-Ser-Arg-Lys-Phe-Ser-Tyr-Lys-Ala
- X1 is a lysine, arginine or histidine residue;
- X2 is a threonine or lysine residue;
- X3 is an aspartate or glutamate residue;
- and
- Pb represents a sequence comprising 5 to 7 amino acids selected from the sequences:
- Val-Thr-Thr-Ser-Glu
- (SEQ ID NO:
- 6)
- Val-Thr-Thr-Ser-Glu-Leu
- (SEQ ID NO:
- 7)
- Val-Thr-Thr-Ser-Glu-Leu-Gly;
- (SEQ ID NO:
- 8)
- or
- a peptide resistant to proteolysis derived from sequence (I) by one or more chemical modification(s).
27 more elements
An isolated peptide consisting of the amino acid sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.