Back to results
US 8,802,738 B2Granted
Polyesters with grafted zwitterions
AssigneeUniversity of Massachusetts
InventorTodd Emrick
Life of this patent
Estimating the term…
Abstract
The invention relates to polymers, such as aliphatic polyesters, with grafted zwitterions. More particularly, the invention relates to polyester-graft-phosphorylcholine polymers prepared by ring-opening polymerization and click chemistry, compositions and products comprising same, and related methods and uses, for example, in drug delivery.
Claims6
A polymer network comprising the following monomer subunits:
- and further comprising at least one of the following monomer subunits:
- wherein
- R1 is a group comprising a zwitterionic moiety selected from sulfobetaine and phosphorylcholine;
- R2, R3, R4, R5, R6 each is independently selected from the group consisting of hydrogen and (C1-C15) alkyl;
- a each is 0, 1, 2, or 3;
- b each is, 1, 2, 3, 4, 5, or 6;
- A is selected from camptothecin, irinotecin, SN-38, and derivatives thereof;
- and
- each of L1′, L2′ and L3′ is independently a linker group linked to A or R1, wherein at least one of L1′, L2′ and L3′ comprises
- wherein the polymer network is crosslinked.
7 more elements
Dependencies are inferred from the claim text.