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US 8,802,726 B2Granted
Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
AssigneeNicox S.A.
InventorsEmilio Clementi, Giulio Cossu, Silvia Brunelli, Ennio Ongini, Daniela Miglietta
Life of this patent
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Abstract
The present invention relates to the use of nitric oxide releasing compounds for retarding or reversing muscular dystrophies such as Duchenne and Becker dystrophies.
Claims4
A method of treating muscular dystrophies comprising administering to a subject a nitric oxide releasing compound of formula (Ia)
- M-X—Y—ONO2 (Ia)
- or enantiomers or diastereoisomers thereof, wherein in the general formula (Ia), M, X and Y have the following meanings:
- M is a residue
- X is —O—, —S— or —NR1—, wherein R1 is H or linear or branched C1-C6 alkyl;
- Y is a bivalent radical having the following meanings:
- straight or branched C1-C20 alkylene being optionally substituted with one or more of the substituents selected from the group consisting of:
- halogen atoms, hydroxy, —ONO2 and T, wherein T is —OC(O)(C1-C10 alkyl)-ONO2 or —O(C1-C10 alkyl)-ONO2;
- or
- —C5-C7 cycloalkylene group optionally substituted with linear or branched C1-C10 alkyl group.
6 more elements
Dependencies are inferred from the claim text.