Transition metal complexes of a bis[thiohydrazine amide] compound
AssigneeSynta Pharmaceuticals Corp.
InventorsMasazumi Nagai, Jianhua Shen
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Abstract
The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.
Claims13
A method of treating a subject with acute myelocytic leukemia, said method comprising administering to the subject an effective amount of a bis[thiohydrazide amide] or a deprotonated form thereof complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by the following Structural Formula:
A method of treating a subject with acute myelocytic leukemia, said method comprising administering to the subject an effective amount of a compound represented by the following structural formula:
- wherein X is a transition metal cation with a +2 charge.
Dependencies are inferred from the claim text.