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US 8,802,702 B2Granted
Compounds for reducing drug resistance and uses thereof
AssigneeThe General Hospital Corporation
InventorsZhenfeng Duan, Francis J. Hornicek
Life of this patent
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Abstract
This invention provides compounds capable of reducing drug resistance in a subject undergoing cancer treatment, methods using the compounds, compositions, and methods for identifying such compounds.
Claims23
A method of reducing drug resistance in a subject undergoing cancer treatment with administration of a chemotherapeutic drug, wherein the cancer is selected from the group consisting of:
- breast, respiratory tract, brain, reproductive organs, digestive tract, urinary tract, eye, liver, head and neck, thyroid, parathyroid, a distant metastasis of a solid tumor, lymphoma, sarcoma, and leukemia, said method comprising administering to a subject in need thereof an effective amount of (2-(4-Methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol or a pharmaceutically acceptable salt thereof, wherein (2-(4-methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol or a pharmaceutically acceptable salt thereof is administered at a dose that is lower than the dose required to produce cytotoxicity in said subject, thereby reducing drug resistance in said subject.
A method for treating cancer in a subject, wherein the cancer is selected from the group consisting of:
- breast, respiratory tract, brain, reproductive organs, digestive tract, urinary tract, eye, liver, head and neck, thyroid, parathyroid, a distant metastasis of a solid tumor, lymphoma, sarcoma, and leukemia, said method comprising a) identifying a subject undergoing cancer treatment with a chemotherapeutic drug and who has developed or is susceptible to developing drug resistance;
- and b) administering to said subject an effective amount of (2-(4-methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol or a pharmaceutically acceptable salt thereof, wherein said effective amount is sufficient to reduce drug resistance in said subject, thereby treating cancer in a subject.
Dependencies are inferred from the claim text.