3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetycholine receptor ligands
AssigneeTargacept, Inc.
InventorsSrinivasa Rao Akireddy, Balwinder Singh Bhatti, Ronald Joseph Heemstra, Srinivasa V. Murthy, Jon-Paul Strachan, Yunde Xiao
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Abstract
The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
Claims6
A compound selected from:
- 3-methylcarbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 3-isopropylcarbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 3-cyclopropylcarbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 3-propoxycarbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 3-isopropoxycarbonyl-3,6-diazabicyclo[3.1.1]heptanes;
- 3-methoxyethoxycarbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 3-(2-fluoroethoxy)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 3-(2-bromofuran-5-yl)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 3-(3-bromofuran-5-yl)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 3-(3-chlorofuran-2-yl)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 3-(isoxazol-5-yl)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 3-(2-methoxyethyl)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 3-(2,2,2-trifluoroethyl)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 3-(tetrahydrofuran-3-yl)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 6-(2-chlorofuran-5-yl)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 6-(2-bromorofuran-5-yl)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 6-cyclobutylcarbonyl-3,6-diazabicyclo[3.1.1]heptane;
- 6-(2-methoxyethyl)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- cis-3-(2-fluorocycloprop-1-yl)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- trans-3-(2-fluorocycloprop-1-yl)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- cis-6-(2-fluorocycloprop-1-yl)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- and
- trans-6-(2-fluorocycloprop-1-yl)carbonyl-3,6-diazabicyclo[3.1.1]heptane;
- or a pharmaceutically acceptable salt thereof.
A compound 3-cyclopropylcarbonyl-3,6-diazabicyclo[3.1.1]heptane or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.