Azaadamantane derivatives and methods of use
AssigneeAbbVie Inc.
InventorsLaura M. Gault, Robert A. Lenz, Ahmed A. Othman
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Abstract
An embodiment relates to a nicotinic acetylcholine receptor ligand, a therapeutically suitable salt, prodrug, or a metabolite thereof, for the prevention and treatment of diseases and conditions that are mediated by nicotinic acetylcholine receptors, and methods of use thereof. Another embodiment is a method of administering a pharmaceutically effective amount of a nicotinic acetylcholine receptor ligand, a therapeutically suitable salt, prodrug, or a metabolite thereof, to a mammal in need thereof.
Claims8
A method for treating Alzheimer's disease or an associated dementia in a subject in need thereof, the method comprising:
- (a) administering to the subject in need thereof once a day, an effective dosage of (4s)-4-(5-phenyl-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.13,7]decane or a salt thereof;
- and
- (b) repeating step (a) for at least 12 weeks;
- wherein the effective dosage is about 75 mg.
Dependencies are inferred from the claim text.